Modified cellulose synthase gene from 'Arabidopsis thaliana' confers herbicide resistance to plants

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Cellulose synthase ('CS'), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene ... continued below

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Somerville, Chris R. & Scieble, Wolf October 11, 2000.

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Cellulose synthase ('CS'), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.

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OSTI as DE00808234

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  • Patent File Date: 2000 Oct 11

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  • Report No.: PATENTS-US-A9686234
  • Grant Number: FG02-94ER20133
  • Office of Scientific & Technical Information Report Number: 808234
  • Archival Resource Key: ark:/67531/metadc736133

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  • October 11, 2000

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  • Oct. 18, 2015, 6:40 p.m.

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  • March 22, 2016, 9:02 p.m.

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Somerville, Chris R. & Scieble, Wolf. Modified cellulose synthase gene from 'Arabidopsis thaliana' confers herbicide resistance to plants, patent, October 11, 2000; United States. (digital.library.unt.edu/ark:/67531/metadc736133/: accessed September 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.