Mass Spectrometric Immunoassay for Parathyroid Hormone Related Protein (PTHrP)

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Description

Many cancers, including prostate, breast and lung express parathyroid hormone related protein (PTHrP). Despite the common tumor overexpression of PTHrP, serum levels of PTHrP are not commonly elevated in affected patients. They postulate that the reasons for the discrepancy between tissue and serum measurements of PTHrP are the inadequate sensitivity and specificity of current PTHrP serum assays. To improve the clinical value of PTHrP serum assays for the cancer patient, they are developing a new generation of novel and ultrasensitive PTHrP serum immunoassays based on immunoaffinity purification, nanospray liquid chromatography tandem mass spectrometry (LC/MS/MS) and accelerator mass spectrometry (AMS).

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139 Kilobytes pages

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Zheng, K.; Rivera, J.D.; Vogel, J.S.; Buchholz, B.A.; Burton, D.W.; Deftos, L.J. et al. June 16, 2000.

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Many cancers, including prostate, breast and lung express parathyroid hormone related protein (PTHrP). Despite the common tumor overexpression of PTHrP, serum levels of PTHrP are not commonly elevated in affected patients. They postulate that the reasons for the discrepancy between tissue and serum measurements of PTHrP are the inadequate sensitivity and specificity of current PTHrP serum assays. To improve the clinical value of PTHrP serum assays for the cancer patient, they are developing a new generation of novel and ultrasensitive PTHrP serum immunoassays based on immunoaffinity purification, nanospray liquid chromatography tandem mass spectrometry (LC/MS/MS) and accelerator mass spectrometry (AMS).

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139 Kilobytes pages

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  • 48th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Long Beach, CA (US), 06/11/2000--06/15/2000

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  • Report No.: UCRL-JC-139327
  • Grant Number: W-7405-Eng-48
  • Office of Scientific & Technical Information Report Number: 793940
  • Archival Resource Key: ark:/67531/metadc735567

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Office of Scientific & Technical Information Technical Reports

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  • June 16, 2000

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  • Oct. 19, 2015, 7:39 p.m.

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  • May 6, 2016, 4 p.m.

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Zheng, K.; Rivera, J.D.; Vogel, J.S.; Buchholz, B.A.; Burton, D.W.; Deftos, L.J. et al. Mass Spectrometric Immunoassay for Parathyroid Hormone Related Protein (PTHrP), article, June 16, 2000; California. (digital.library.unt.edu/ark:/67531/metadc735567/: accessed November 18, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.