Functional genomics, an integrated approach. Final report for the Trieste component

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Phage display offers the possibility of selecting polypeptides (and the genes which encode them) from libraries of 10 billion or more different polypeptides on the basis of their abilities to bind target proteins and subdomains. The general principle of phage display relies on the coupling of phenotype and genotype in the phage. The specific aims of this project were threefold: (1) to produce a large phagemid antibody library; (2) to develop a general method for deriving antibodies against the protein products of cloned genes; (3) to develop technologies which permit the display of gene fragment libraries on phage. Accomplishments in ... continued below

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Medium: P; Size: 8 Pages

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Bradbury, Andrew November 1, 1999.

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Description

Phage display offers the possibility of selecting polypeptides (and the genes which encode them) from libraries of 10 billion or more different polypeptides on the basis of their abilities to bind target proteins and subdomains. The general principle of phage display relies on the coupling of phenotype and genotype in the phage. The specific aims of this project were threefold: (1) to produce a large phagemid antibody library; (2) to develop a general method for deriving antibodies against the protein products of cloned genes; (3) to develop technologies which permit the display of gene fragment libraries on phage. Accomplishments in each of these areas are presented.

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Medium: P; Size: 8 Pages

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  • Report No.: DOE/ER/62647--1
  • Grant Number: FG02-98ER62647
  • DOI: 10.2172/810688 | External Link
  • Office of Scientific & Technical Information Report Number: 810688
  • Archival Resource Key: ark:/67531/metadc735004

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  • November 1, 1999

Added to The UNT Digital Library

  • Oct. 18, 2015, 6:40 p.m.

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  • Nov. 3, 2016, 12:24 p.m.

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Bradbury, Andrew. Functional genomics, an integrated approach. Final report for the Trieste component, report, November 1, 1999; Los Alamos, New Mexico. (digital.library.unt.edu/ark:/67531/metadc735004/: accessed December 10, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.