Intracellular localization of titanium dioxide-biomolecule nanocomposites.

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Emerging areas of nanotechnology hold the promise of overcoming the limitations of existing technology for intracellular manipulation. These new developments include the creation of nanocomposites that can be introduced into the cells, targeted to specific subcellular sites, and subsequently used as platforms for initiation of intracellular processes dependent on or aided by locally high concentrations of specific molecules delivered as components of the nanocomposites. Nanocomposites that combine functional properties of biomolecules with the functional properties of inorganic components could provide new tools for biology, medicine, chemistry and material sciences. Here we describe how we introduced TiO{sub 2}-DNA nanocomposites into cells, ... continued below

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Paunesku, T.; Stojicevic, N.; Vogt, S.; Maser, J.; Lai, B.; Rajh, T. et al. October 30, 2002.

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Emerging areas of nanotechnology hold the promise of overcoming the limitations of existing technology for intracellular manipulation. These new developments include the creation of nanocomposites that can be introduced into the cells, targeted to specific subcellular sites, and subsequently used as platforms for initiation of intracellular processes dependent on or aided by locally high concentrations of specific molecules delivered as components of the nanocomposites. Nanocomposites that combine functional properties of biomolecules with the functional properties of inorganic components could provide new tools for biology, medicine, chemistry and material sciences. Here we describe how we introduced TiO{sub 2}-DNA nanocomposites into cells, and localized titanium in the cells by mapping the Ti K{alpha} X-ray fluorescence induced at the 2-ID-E microprobe of the SRI-CAT at the Advanced Photon Source at Argonne National Laboratory.

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  • 7th International Conference on X-ray Microscope (XRM 2002), Grenoble (FR), 07/29/2002--08/02/2002

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  • Report No.: ANL/XFD/CP-108965
  • Grant Number: W-31-109-ENG-38
  • Office of Scientific & Technical Information Report Number: 803882
  • Archival Resource Key: ark:/67531/metadc734760

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  • October 30, 2002

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  • Oct. 19, 2015, 7:39 p.m.

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  • March 25, 2016, noon

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Paunesku, T.; Stojicevic, N.; Vogt, S.; Maser, J.; Lai, B.; Rajh, T. et al. Intracellular localization of titanium dioxide-biomolecule nanocomposites., article, October 30, 2002; Illinois. (digital.library.unt.edu/ark:/67531/metadc734760/: accessed November 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.