SATB1 targets chromatin remodeling to regulate genes over long distances Page: 1 of 11
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SATB1 targets chromatin remodeling to regulate genes over long distances
Dag Yasui , Masaru Miyano*, Shutao Cai , Patrick Varga-Weisz and Terumi Kohwi-
Shigematsut
*
Lawrence Berkeley National Laboratory, Life Sciences Division, University of California Berkeley
94720. tMarie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL.$ corresponding author
Terumi Kohwi-Shigematsu
Lawrence Berkeley Laboratory
1 Cyclotron Rd (mail stop 84-171)
University of California
Berkeley, CA 94720
TEL 510-486-4983
FAX 510-486-4545
email terumiks@lbl.gov
How eukaryotic chromosomes are organized inside the nucleus allowing only a subset of the genome
to be expressed in any given cell type is largely unknown 1-3. SATB1, a protein found
predominantly in thymocytes4 regulates genes by folding chromatin into loop domains, tethering
specialized DNA elements to a SATB 1 network structure 5. SATB 1 ablation by gene targeting
results in temporal and spatial miss-expression of numerous genes and arrested T cell development,
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Yasui, Dag; Miyano, Masaru; Cai, Shutao; Varga-Weisz, Patrick & Kohwi-Shigematsu, Terumi. SATB1 targets chromatin remodeling to regulate genes over long distances, article, September 18, 2002; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc733622/m1/1/: accessed April 24, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.