Human Genetic Marker for Resistance to Radiation and Chemicals

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Description

TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in ... continued below

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Lieberman, DR. Howard B. May 11, 2001.

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Description

TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage.

Physical Description

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Notes

INIS; OSTI as DE00789807

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  • Other Information: PBD: 11 May 2001

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  • Report No.: DOE/ER/62309
  • Grant Number: FG07-96ER62309
  • DOI: 10.2172/789807 | External Link
  • Office of Scientific & Technical Information Report Number: 789807
  • Archival Resource Key: ark:/67531/metadc723851

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • May 11, 2001

Added to The UNT Digital Library

  • Sept. 29, 2015, 5:31 a.m.

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  • Jan. 4, 2017, 1:50 p.m.

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Lieberman, DR. Howard B. Human Genetic Marker for Resistance to Radiation and Chemicals, report, May 11, 2001; United States. (digital.library.unt.edu/ark:/67531/metadc723851/: accessed December 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.