Graphical Analysis of PET Data Applied to Reversible and Irreversible Tracers

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Description

Graphical analysis refers to the transformation of multiple time measurements of plasma and tissue uptake data into a linear plot, the slope of which is related to the number of available tracer binding sites. This type of analysis allows easy comparisons among experiments. No particular model structure is assumed, however it is assumed that the tracer is given by bolus injection and that both tissue uptake and the plasma concentration of unchanged tracer are monitored following tracer injection. The requirement of plasma measurements can be eliminated in some cases when a reference region is available. There are two categories of ... continued below

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29 p.

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Logan, Jean November 18, 1999.

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Description

Graphical analysis refers to the transformation of multiple time measurements of plasma and tissue uptake data into a linear plot, the slope of which is related to the number of available tracer binding sites. This type of analysis allows easy comparisons among experiments. No particular model structure is assumed, however it is assumed that the tracer is given by bolus injection and that both tissue uptake and the plasma concentration of unchanged tracer are monitored following tracer injection. The requirement of plasma measurements can be eliminated in some cases when a reference region is available. There are two categories of graphical methods which apply to two general types of ligands--those which bind reversibly during the scanning procedure and those which are irreversible or trapped during the time of the scanning procedure.

Physical Description

29 p.

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OSTI as DE00770712

Medium: P; Size: 29 pages

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  • Quantitative Analysis of Tumor Biochemistry Using PET and SPECT, Bethesda, MD (US), 11/18/1999--11/19/1999

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  • Report No.: BNL-66999
  • Grant Number: AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 770712
  • Archival Resource Key: ark:/67531/metadc723417

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  • November 18, 1999

Added to The UNT Digital Library

  • Sept. 29, 2015, 5:31 a.m.

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  • April 10, 2017, 7:07 p.m.

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Logan, Jean. Graphical Analysis of PET Data Applied to Reversible and Irreversible Tracers, article, November 18, 1999; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc723417/: accessed September 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.