Molecular Mechanism of Biological Proton Transport

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Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

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Pomes, R. September 1, 1998.

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Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

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Medium: P; Size: vp.

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OSTI as DE00758933

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  • 3rd Conference on Biological Physics, Santa Fe, NM (US), 09/1998

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  • Report No.: LA-UR-99-1067
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 758933
  • Archival Resource Key: ark:/67531/metadc711844

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  • September 1, 1998

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  • Sept. 12, 2015, 6:31 a.m.

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  • July 28, 2016, 7:20 p.m.

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Pomes, R. Molecular Mechanism of Biological Proton Transport, article, September 1, 1998; New Mexico. (digital.library.unt.edu/ark:/67531/metadc711844/: accessed June 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.