PATTERNS OF TUBULAR PROTEINURIA FROM METALS AND SOLVENTS

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Using modern technology, minute quantities of low-molecular-weight-proteins (LMWP), prostanoids, growth factors, and intrarenal and extrarenal enzymes can be measured in urine. Excretory patterns that are characteristic for the site and mechanism of renal injury often can be found. It is possible to recognize urinary biomarker patterns that suggest the putative environmental nephrotoxin. This fingerprinting approach has become an effective tool in recent years as urine from cohorts with known occupational nephrotoxin exposures has been analyzed for patterns of specific constituents in European cooperative studies. The authors' studies performed on subjects with occupational and environmental exposures in New Jersey confirm the ... continued below

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13 pages

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WEDEEN,R.P.; UDASIN,I.; FIEDLER,N.; D'HAESE,P.; DEBROE,M.E.; GELPI,E. et al. December 1, 1998.

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Description

Using modern technology, minute quantities of low-molecular-weight-proteins (LMWP), prostanoids, growth factors, and intrarenal and extrarenal enzymes can be measured in urine. Excretory patterns that are characteristic for the site and mechanism of renal injury often can be found. It is possible to recognize urinary biomarker patterns that suggest the putative environmental nephrotoxin. This fingerprinting approach has become an effective tool in recent years as urine from cohorts with known occupational nephrotoxin exposures has been analyzed for patterns of specific constituents in European cooperative studies. The authors' studies performed on subjects with occupational and environmental exposures in New Jersey confirm the pattern specificity and threshold effects for chromium, mercury and lead. In addition, they have been able to show that increased N-acetylglucosaminidase excretion following lead exposure correlates with current (blood lead) but not with cumulative (bone lead) exposure. The success of recent cooperative efforts has been in part due to the absence of clinical renal failure in study subjects. Urinary biomarkers indicate early renal injury. As renal failure progresses, excretory patterns become nonspecific. Moreover, renal injury that results in tubular proteinuria may not progress to renal failure. Nevertheless, biomarkers of renal injury can help establish acceptable exposure levels and identify the need for long-term surveillance to ascertain when clinical renal disease may result.

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13 pages

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OSTI as DE00755022

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  • BIOMARKERS, THE GENOME AND THE INDIVIDUAL, CHARLESTON, SC (US), 05/04/1997--05/08/1997

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  • Report No.: BNL--66853
  • Report No.: NA
  • Grant Number: AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 755022
  • Archival Resource Key: ark:/67531/metadc711080

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 1, 1998

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  • Sept. 12, 2015, 6:31 a.m.

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  • Nov. 9, 2015, 8:19 p.m.

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WEDEEN,R.P.; UDASIN,I.; FIEDLER,N.; D'HAESE,P.; DEBROE,M.E.; GELPI,E. et al. PATTERNS OF TUBULAR PROTEINURIA FROM METALS AND SOLVENTS, article, December 1, 1998; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc711080/: accessed October 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.