Nominal effective radiation doses delivered during clinical trials of boron neutron capture therapy

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Boron neutron capture therapy (BNCT) is a binary system that, in theory, should selectively deliver lethal, high linear energy transfer (LET) radiation to tumor cells dispersed within normal tissues. It is based on the nuclear reaction 10-B(n, {alpha})7-Li, which occurs when the stable nucleus of boron-10 captures a thermal neutron. Due to the relatively high cross-section of the 10-B nucleus for thermal neutron capture and short ranges of the products of this reaction, tumor cells in the volume exposed to thermal neutrons and containing sufficiently high concentration of 10-B would receive a much higher radiation dose than the normal cells ... continued below

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8 p.

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Capala, J.; Diaz, A.Z. & Chanana, A.D. December 31, 1997.

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Description

Boron neutron capture therapy (BNCT) is a binary system that, in theory, should selectively deliver lethal, high linear energy transfer (LET) radiation to tumor cells dispersed within normal tissues. It is based on the nuclear reaction 10-B(n, {alpha})7-Li, which occurs when the stable nucleus of boron-10 captures a thermal neutron. Due to the relatively high cross-section of the 10-B nucleus for thermal neutron capture and short ranges of the products of this reaction, tumor cells in the volume exposed to thermal neutrons and containing sufficiently high concentration of 10-B would receive a much higher radiation dose than the normal cells contained within the exposed volume. Nevertheless, radiation dose deposited in normal tissue by gamma and fast neutron contamination of the neutron beam, as well as neutron capture in nitrogen, 14-N(n,p)14-C, hydrogen, 1-H(n,{gamma})2-H, and in boron present in blood and normal cells, limits the dose that can be delivered to tumor cells. It is, therefore, imperative for the success of the BNCT the dosed delivered to normal tissues be accurately determined in order to optimize the irradiation geometry and to limit the volume of normal tissue exposed to thermal neutrons. These are the major objectives of BNCT treatment planning.

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8 p.

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INIS; OSTI as DE98001907

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  • 5. international conference on dose, time and fractionation in radiation oncology, Madison, WI (United States), 10-13 Sep 1997

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  • Other: DE98001907
  • Report No.: BNL--65104
  • Report No.: CONF-9709182--
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 663501
  • Archival Resource Key: ark:/67531/metadc710811

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 31, 1997

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  • Sept. 12, 2015, 6:31 a.m.

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  • Nov. 5, 2015, 1:21 p.m.

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Capala, J.; Diaz, A.Z. & Chanana, A.D. Nominal effective radiation doses delivered during clinical trials of boron neutron capture therapy, article, December 31, 1997; United States. (digital.library.unt.edu/ark:/67531/metadc710811/: accessed November 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.