Use of a new tandem cation/anion exchange system with clinical-scale generators provides high specific volume solutions of technetium-99m and rhenium-188

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In this paper the authors describe the first application of a simple and inexpensive post elution tandem cation-anion exchange column system which is based on generator elution with salts of weak acids such as ammonium acetate instead of saline solution to provide very high specific volume solutions of technetium-99m and rhenium-188 from clinical scale molybdenum-99/technetium-99m generator prepared from low specific activity (n,y) molybdenum-99, and tungsten-188/rhenium-188 generators, respectively. Initial passage of the bolus through a strong cation exchange cartridge converts the ammonium acetate to acetic acid which is essentially not ionized at the acidic pH, allowing specific subsequent amine type (QMA ... continued below

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11 p.

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Knapp, F.R. Jr.; Beets, A.L.; Mirzadeh, S. & Guhlke, S. March 1, 1998.

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In this paper the authors describe the first application of a simple and inexpensive post elution tandem cation-anion exchange column system which is based on generator elution with salts of weak acids such as ammonium acetate instead of saline solution to provide very high specific volume solutions of technetium-99m and rhenium-188 from clinical scale molybdenum-99/technetium-99m generator prepared from low specific activity (n,y) molybdenum-99, and tungsten-188/rhenium-188 generators, respectively. Initial passage of the bolus through a strong cation exchange cartridge converts the ammonium acetate to acetic acid which is essentially not ionized at the acidic pH, allowing specific subsequent amine type (QMA SepPak{trademark}) anion exchange cartridge column trapping of the microscopic levels of the pertechnetate or perrhenate. Subsequent elution of the anion cartridge with a small volume (< 1 mL) of saline then provides high specific volume solutions of technetium-99m by concentration of the high eluant volumes obtained by elution of clinical-scale (1 Ci) generators. This new approach also works very effectively to obtain high specific volume solutions of rhenium-188 (> 500 mCi/mL) from the alumina-based tungsten-188/rhenium-188 generator.

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11 p.

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INIS; OSTI as DE98003387

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  • International symposium on modern trends in pharmaceuticals for diagnosis, Lisbon (Portugal), 30 Mar - 3 Apr 1998

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  • Other: DE98003387
  • Report No.: ORNL/CP--96890
  • Report No.: CONF-980348--
  • Grant Number: AC05-96OR22464
  • Office of Scientific & Technical Information Report Number: 650214
  • Archival Resource Key: ark:/67531/metadc709129

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • March 1, 1998

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  • Sept. 12, 2015, 6:31 a.m.

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  • Jan. 25, 2016, 12:26 p.m.

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Knapp, F.R. Jr.; Beets, A.L.; Mirzadeh, S. & Guhlke, S. Use of a new tandem cation/anion exchange system with clinical-scale generators provides high specific volume solutions of technetium-99m and rhenium-188, article, March 1, 1998; Tennessee. (digital.library.unt.edu/ark:/67531/metadc709129/: accessed October 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.