Multi-mutational model for cancer based on age-time patterns of radiation effects: 2. Biological aspects

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Biological properties of relevance when modeling cancers induced in the atom bomb survivors include the wide distribution of the induced cancers across all organs, their biological indistinguishability from background cancers, their rates being proportional to background cancer rates, their rates steadily increasing over at least 50 years as the survivors age, and their radiation dose response being linear. We have successfully described this array of properties with a modified Armitage-Doll model using 5 to 6 somatic mutations, no intermediate growth, and the dose-related replacement of any one of these time-driven mutations by a radiation-induced mutation. Such a model is contrasted ... continued below

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14 p.

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Mendelsohn, M.L. & Pierce, P.A. September 4, 1997.

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Biological properties of relevance when modeling cancers induced in the atom bomb survivors include the wide distribution of the induced cancers across all organs, their biological indistinguishability from background cancers, their rates being proportional to background cancer rates, their rates steadily increasing over at least 50 years as the survivors age, and their radiation dose response being linear. We have successfully described this array of properties with a modified Armitage-Doll model using 5 to 6 somatic mutations, no intermediate growth, and the dose-related replacement of any one of these time-driven mutations by a radiation-induced mutation. Such a model is contrasted to prevailing models that use fewer mutations combined with intervening growth. While the rationale and effectiveness of our model is compelling for carcinogenesis in the atom bomb survivors, the lack of a promotional component may limit the generality of the model for other types of human carcinogenesis.

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14 p.

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OSTI as DE98057430

Other: FDE: PDF; PL:

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  • International conference on low doses of ionizing radiation: biological effects and regulatory control, Seville (Spain), 17-21 Nov 1997

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  • Other: DE98057430
  • Report No.: UCRL-JC--128583
  • Report No.: CONF-971123--
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 649228
  • Archival Resource Key: ark:/67531/metadc708309

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  • September 4, 1997

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  • Sept. 12, 2015, 6:31 a.m.

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  • April 10, 2017, 1:39 p.m.

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Mendelsohn, M.L. & Pierce, P.A. Multi-mutational model for cancer based on age-time patterns of radiation effects: 2. Biological aspects, article, September 4, 1997; California. (digital.library.unt.edu/ark:/67531/metadc708309/: accessed July 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.