Design of a protocol for combined laser hyperthermia-photodynamic therapy in the esophagus

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Photodynamic laser therapy (PDT) for esophageal cancer has recently been studied in animal and clinical trials. In several animal experiments a synergetic effect was found by simultaneously applying PDT and hyperthermia (HT). In this paper an optical fiber system is described which can be used in the esophagus for combined PDT with a 1 W dye laser and HT with a 15--40 W Nd-YAG laser. Phantoms were developed to simulate the geometry of the esophagus using cow muscle. The spatial-temporal temperature field during HT was measured. The results were compared with calculations using a coupled Monte Carlo laser transport/finite difference ... continued below

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186 Kilobytes pages

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London, R A; Eichler, J; Liebetrudt, J & Ziegenhagen, L February 1, 2000.

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Description

Photodynamic laser therapy (PDT) for esophageal cancer has recently been studied in animal and clinical trials. In several animal experiments a synergetic effect was found by simultaneously applying PDT and hyperthermia (HT). In this paper an optical fiber system is described which can be used in the esophagus for combined PDT with a 1 W dye laser and HT with a 15--40 W Nd-YAG laser. Phantoms were developed to simulate the geometry of the esophagus using cow muscle. The spatial-temporal temperature field during HT was measured. The results were compared with calculations using a coupled Monte Carlo laser transport/finite difference heat transport model using the LATIS computer program. Measurements and calculations yield a realistic description of the temperature distribution during HT under various experimental conditions. The LATIS program allows the prediction of the effects of blood perfusion for in-vivo situations. The results show that the perfusion has considerable influence on the temperature field, which must be considered for in-vivo applications.

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186 Kilobytes pages

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  • Proceedings of Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems, SPIE, Bellingham, WA (US), 01/22/2000--01/23/2000

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  • Report No.: UCRL-JC-137167
  • Report No.: KP1401030
  • Report No.: ERD-97-056
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 756786
  • Archival Resource Key: ark:/67531/metadc706833

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • February 1, 2000

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  • Sept. 12, 2015, 6:31 a.m.

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  • May 6, 2016, 1:11 p.m.

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London, R A; Eichler, J; Liebetrudt, J & Ziegenhagen, L. Design of a protocol for combined laser hyperthermia-photodynamic therapy in the esophagus, article, February 1, 2000; California. (digital.library.unt.edu/ark:/67531/metadc706833/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.