Nuclear medicine program progress report for quarter ending December 31, 1996

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In this report the authors describe the use of an effective method for concentration of the rhenium-188 bolus and the results of the first Phase 1 clinical studies for bone pain palliation with rhenium-188 obtained from the tungsten-188/rhenium-188 generator. Initial studies with therapeutic levels of Re-188-HEDP at the Clinic for Nuclear Medicine at the University of Bonn, Germany, have demonstrated the expected good metastatic uptake of Re-188-HEDP in four patients who presented with skeletal metastases from disseminated prostatic cancer with good pain palliation and minimal marrow suppression. In addition, skeletal metastatic targeting of tracer doses of Re-188(V)-DMSA has been evaluated ... continued below

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35 p.

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Knapp, F.F. Jr.; Beets, A.L.; Boll, R.; Luo, H.; McPherson, D.W. & Mirzadeh, S. March 20, 1997.

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Description

In this report the authors describe the use of an effective method for concentration of the rhenium-188 bolus and the results of the first Phase 1 clinical studies for bone pain palliation with rhenium-188 obtained from the tungsten-188/rhenium-188 generator. Initial studies with therapeutic levels of Re-188-HEDP at the Clinic for Nuclear Medicine at the University of Bonn, Germany, have demonstrated the expected good metastatic uptake of Re-188-HEDP in four patients who presented with skeletal metastases from disseminated prostatic cancer with good pain palliation and minimal marrow suppression. In addition, skeletal metastatic targeting of tracer doses of Re-188(V)-DMSA has been evaluated in several patients with metastases from prostatic cancer at the Department of Nuclear Medicine at the Canterbury and Kent Hospital in Canterbury, England. In this report the authors also describe further studies with the E-(R,R)-IQNP ligand developed in the ORNL Nuclear Medicine Program as a potential imaging agent for detection of changes which may occur in the cerebral muscarinic-cholinergic receptors (mAChR) in Alzheimer`s and other diseases.

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35 p.

Notes

OSTI as DE98003638

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  • Other Information: PBD: 20 Mar 1997

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  • Other: DE98003638
  • Report No.: ORNL/TM--13353
  • Grant Number: AC05-96OR22464
  • DOI: 10.2172/656448 | External Link
  • Office of Scientific & Technical Information Report Number: 656448
  • Archival Resource Key: ark:/67531/metadc706814

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  • March 20, 1997

Added to The UNT Digital Library

  • Sept. 12, 2015, 6:31 a.m.

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  • Jan. 25, 2016, 6:47 p.m.

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Knapp, F.F. Jr.; Beets, A.L.; Boll, R.; Luo, H.; McPherson, D.W. & Mirzadeh, S. Nuclear medicine program progress report for quarter ending December 31, 1996, report, March 20, 1997; Tennessee. (digital.library.unt.edu/ark:/67531/metadc706814/: accessed December 9, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.