Expression of cytoskeletal and matrix genes following exposure to ionizing radiation: Dose-rate effects and protein synthesis requirements Page: 1 of 18
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IAL FOR SUBM'SSON
1
For submission to FEBS Letters
Expression of Cytoskeletal and Matrix Genes Following
Exposure to Ionizing Radiation: Dose-rate Effects
and Protein Synthesis Requirements
Gayle E. Woloschak,1,2,3 Paolo Felcher,' and Chin-Mei Chang-Liu'
'Center for Mechanistic Biology and Biotechnology
Argonne National Laboratory
9700 South Cass Avenue
Argonne, Illinois 60439-4811
'Phone (708)252-3312/Fax (708)252-3387
2Department of Pathology
Loyola University Medical Center
2160 South First Avenue
Maywood, Illinois 60153
Key Words: ionizing radiation, cytoskeletal elements, matrix elements, dose-rate
effects, protein synthesis inhibitors, gene expression
ABSTRACT
Experiments examined the effects of radiation dose-rate and protein synthesis
inhibition expression of cytoskeletal and matrix elements in Syrian hamster embryo
cells. Results demonstrated little effect of dose-rate for neutrons when comparing
expression of a-tubulin and fibronectin genes. Cycloheximide repressed accumulation
of a-tubulin-mRNA following exposure to high dose-rate neutrons or y rays.
3To whom correspondence should be addressed at Center for Mechanistic Biology and
Biotechnology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL
60439-4833
The submitted manuscript has been authored
by a contractor of the U. S. Governmnt
under contract No. W-31-109ENG-3g-
Accordingly, the U. S. Government retains A
nonexclus.ie, royalty-free license to publish
ri" t},. ' - +S "or reproduce the Published form~ of this
pro Ucontribution, or allow oOthers to do W. for
,l~i~i~. S. Government purposes-
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Woloschak, Gayle E.; Felcher, Paolo & Chang-Liu, Chin-Mei. Expression of cytoskeletal and matrix genes following exposure to ionizing radiation: Dose-rate effects and protein synthesis requirements, report, June 1, 1995; Illinois. (https://digital.library.unt.edu/ark:/67531/metadc706787/m1/1/: accessed March 19, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.