Radioimmunotargeting With Modified Streptavidin-Biotin. Final Report Metadata

Metadata describes a digital item, providing (if known) such information as creator, publisher, contents, size, relationship to other resources, and more. Metadata may also contain "preservation" components that help us to maintain the integrity of digital files over time.

Available Formats

Dublin Core: XML Dublin Core: JSON Dublin Core: Text Dublin Core: RDF/XML UNTL: XML Access METS: XML

Title

  • Main Title Radioimmunotargeting With Modified Streptavidin-Biotin. Final Report

Creator

  • Author: Cantor, C. R.
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Energy Research.
    Contributor Type: Organization
    Contributor Info: USDOE Office of Energy Research, Washington, DC (United States)

Publisher

  • Name: Boston University
    Place of Publication: Boston, Massachusetts
    Additional Info: Boston Univ., MA (United States)

Date

  • Creation: 1998-09-01

Language

  • English

Description

  • Content Description: For the past three years, the author has designed and produced several useful streptavidin variants, characterized their properties both in vitro and in vivo, and developed methods and strategies needed for characterization of each molecule and the entire radioimmunotargeting approaches using these molecules. In molecular design of these streptavidin mutants, an enhanced molecular modeling method, including empirical free energy calculations was used which is of great assistance in designing streptavidin mutants effectively and intelligently. When the original proposal was submitted in 1992, the reviewers were rather skeptical about the proposal to design successfully a various streptavidin mutants, particularly a dimeric streptavidin and multi-flavor streptavidins. These were clearly very challenging tasks, but now the author has the molecules in hand. This demonstrates the power of the molecular modeling method he is using and suggests the feasibility of further enhancements of these and other streptavidin variants by the molecular modeling capability. The author has also developed signal amplification methods which could introduce large amounts of radioisotopes specifically at target tumor sites in the radioimmunotargeting approaches.
  • Physical Description: 18 p.

Subject

  • Keyword: Radiopharmaceuticals
  • Keyword: Progress Report
  • Keyword: Mathematical Models
  • STI Subject Categories: 55 Biology And Medicine, Basic Studies
  • Keyword: Ligands
  • Keyword: Biotin
  • Keyword: Proteins
  • Keyword: Experimental Data
  • Keyword: Biochemical Reaction Kinetics

Source

  • Other Information: PBD: [1998]

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Other: DE98006369
  • Report No.: DOE/ER/61656--T1
  • Grant Number: FG02-93ER61656
  • DOI: 10.2172/656479
  • Office of Scientific & Technical Information Report Number: 656479
  • Archival Resource Key: ark:/67531/metadc706257

Note

  • Display Note: INIS; OSTI as DE98006369
  • Display Note: Medium: P; Size: 18 p.
Back to Top of Screen