Synthetic thrombus model for in vitro studies of laser thrombolysis

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Laser thrombolysis is the controlled ablation of a thrombus (blood clot) blockage in a living arterial system. Theoretical modeling of the interaction of laser light with thrombi relies on the ability to perform in vitro experiments with well characterized surrogate materials. A synthetic thrombus formulation may offer more accurate results when compared to in vivo clinical experiments. The authors describe the development of new surrogate materials based on formulations incorporating chick egg, guar gum, modified food starch, and a laser light absorbing dye. The sound speed and physical consistency of the materials were very close to porcine (arterial) and human ... continued below

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[50] p.

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Hermes, R.E. & Trajkovska, K. July 1, 1998.

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Description

Laser thrombolysis is the controlled ablation of a thrombus (blood clot) blockage in a living arterial system. Theoretical modeling of the interaction of laser light with thrombi relies on the ability to perform in vitro experiments with well characterized surrogate materials. A synthetic thrombus formulation may offer more accurate results when compared to in vivo clinical experiments. The authors describe the development of new surrogate materials based on formulations incorporating chick egg, guar gum, modified food starch, and a laser light absorbing dye. The sound speed and physical consistency of the materials were very close to porcine (arterial) and human (venous) thrombi. Photographic and videotape recordings of pulsed dye laser ablation experiments under various experimental conditions were used to evaluate the new material as compared to in vitro tests with human (venous) thrombus. The characteristics of ablation and mass removal were similar to that of real thrombi, and therefore provide a more realistic model for in vitro laser thrombolysis when compared to gelatin.

Physical Description

[50] p.

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OSTI as DE98003497

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  • BIOS `98: an international symposium on biomedical optics, San Jose, CA (United States), 24-30 Jan 1998

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  • Other: DE98003497
  • Report No.: LA-UR--98-294
  • Report No.: CONF-980117--
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 663511
  • Archival Resource Key: ark:/67531/metadc704709

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  • July 1, 1998

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  • Sept. 12, 2015, 6:31 a.m.

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  • Feb. 29, 2016, 7:48 p.m.

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Hermes, R.E. & Trajkovska, K. Synthetic thrombus model for in vitro studies of laser thrombolysis, article, July 1, 1998; New Mexico. (digital.library.unt.edu/ark:/67531/metadc704709/: accessed July 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.