A new approach to the analysis of radiopharmaceuticals. Final technical report, January 15, 1987--June 30, 1991

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The objective of this research was to investigate analytical techniques that could be used in the study of both the basic chemistry and the radiopharmaceutical chemistry of {sup 99m}Tc. First funded in 1981, the work focused initially upon the use of high performance liquid chromatography (HPLC) and various forms of mass spectrometry for the identification of technetium species. This funding allowed the authors to combine HPLC and mass spectrometry to identify radiopharmaceuticals which, although in clinical use, had not previously been characterized. Other techniques that have been examined include resonance Raman spectroscopy and, more significantly, {sup 99}Tc nuclear magnetic resonance ... continued below

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16 p.

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Jones, A.G.; Davison, A. & Costello, C.E. March 1, 1998.

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Description

The objective of this research was to investigate analytical techniques that could be used in the study of both the basic chemistry and the radiopharmaceutical chemistry of {sup 99m}Tc. First funded in 1981, the work focused initially upon the use of high performance liquid chromatography (HPLC) and various forms of mass spectrometry for the identification of technetium species. This funding allowed the authors to combine HPLC and mass spectrometry to identify radiopharmaceuticals which, although in clinical use, had not previously been characterized. Other techniques that have been examined include resonance Raman spectroscopy and, more significantly, {sup 99}Tc nuclear magnetic resonance spectroscopy (NMR), with the latter not only being used in purely chemical experiments but also in biologic studies. In 1985 a grant to the Department of Chemistry at MIT from DOE allowed the purchase of an X-ray diffractometer and access to this instrument has enabled them to broaden the analytical base with routine structural determinations.

Physical Description

16 p.

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INIS; OSTI as DE99000034

Medium: P; Size: 16 p.

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  • Other Information: PBD: Mar 1998

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  • Other: DE99000034
  • Report No.: DOE/ER/60526--002
  • Grant Number: FG02-87ER60526
  • DOI: 10.2172/666229 | External Link
  • Office of Scientific & Technical Information Report Number: 666229
  • Archival Resource Key: ark:/67531/metadc704466

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  • March 1, 1998

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  • Sept. 12, 2015, 6:31 a.m.

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  • April 10, 2017, 2:42 p.m.

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Jones, A.G.; Davison, A. & Costello, C.E. A new approach to the analysis of radiopharmaceuticals. Final technical report, January 15, 1987--June 30, 1991, report, March 1, 1998; Cambridge, Massachusetts. (digital.library.unt.edu/ark:/67531/metadc704466/: accessed September 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.