Evaluation of a Subunit Vaccine to Infectious Hematopoietic Necrosis Virus, 1986 Annual Report.

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Description

The nucleotide sequence of the IHNV glycoprotein gene has been determined from a cDNA clone containing the entire coding region. The glycoprotein cDNA clone contained a leader sequence of 48 bases, a coding region of 1524 nucleotides, and 39 bases at the 3 foot end. The entire cDNA clone contains 1609 nucleodites and encodes a protein of 508 amino acids. The deduced amino acid sequence gave a translated molecular weight of 56,795 daltons. A hydropathicity profile of the deduced amino acid sequence indicated that there were two major hydrophobic domains: one,at the N-terminus,delineating a signal peptide of 18 amino acids ... continued below

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29 pages

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Leong, JoAnn Ching September 1, 1986.

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Description

The nucleotide sequence of the IHNV glycoprotein gene has been determined from a cDNA clone containing the entire coding region. The glycoprotein cDNA clone contained a leader sequence of 48 bases, a coding region of 1524 nucleotides, and 39 bases at the 3 foot end. The entire cDNA clone contains 1609 nucleodites and encodes a protein of 508 amino acids. The deduced amino acid sequence gave a translated molecular weight of 56,795 daltons. A hydropathicity profile of the deduced amino acid sequence indicated that there were two major hydrophobic domains: one,at the N-terminus,delineating a signal peptide of 18 amino acids and the other, at the C-terminus,delineating the region of the transmembrane. Five possible sites of N-linked glyscoylation were identified. Although no nucleic acid homology existed between the IHNV glycoprotein gene and the glycoprotein genes of rabies and VSV, there was significant homology at the amino acid level between all three rhabdovirus glycoproteins.

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29 pages

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  • Other Information: PBD: 1 Sep 1986

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  • Report No.: DOE/BP-16479-2
  • Grant Number: 1984BP16479
  • DOI: 10.2172/758122 | External Link
  • Office of Scientific & Technical Information Report Number: 758122
  • Archival Resource Key: ark:/67531/metadc702827

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Office of Scientific & Technical Information Technical Reports

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  • September 1, 1986

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  • Sept. 12, 2015, 6:31 a.m.

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Leong, JoAnn Ching. Evaluation of a Subunit Vaccine to Infectious Hematopoietic Necrosis Virus, 1986 Annual Report., report, September 1, 1986; United States. (digital.library.unt.edu/ark:/67531/metadc702827/: accessed November 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.