[Sequencing by hybridization methods to generate large arrays of oligonucleotides]. Final technical report

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The subject of this project is to address a pressing need for custom DNA microarrays (chips) which can be easily and at low cost formatted and revised for research. In this sense, the term custom means chips for which there is need for limited quantities (less than hundreds) of any particular chip design which contains a large number of different, users defined sequences. Of the three principal approaches to fabricate DNA microarrays, the two which have been commercialized (a and b below) are not particularly suited to research purposes because of the significant time and costs required, once a result … continued below

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16 pages

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Creator: Unknown. December 31, 1996.

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This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by the UNT Libraries Government Documents Department to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 15 times. More information about this report can be viewed below.

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Description

The subject of this project is to address a pressing need for custom DNA microarrays (chips) which can be easily and at low cost formatted and revised for research. In this sense, the term custom means chips for which there is need for limited quantities (less than hundreds) of any particular chip design which contains a large number of different, users defined sequences. Of the three principal approaches to fabricate DNA microarrays, the two which have been commercialized (a and b below) are not particularly suited to research purposes because of the significant time and costs required, once a result is obtained, to utilize that result in the design of a new and better chip: (a) the photodeprotection scheme used by Affymetrix; and (b) the spotting of pre-synthesized oligos or c-DNA onto surfaces.

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16 pages

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OSTI as DE00639709

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  • Other Information: Supercedes report DE98007343

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  • Other: DE98007343
  • Report No.: DOE/ER/62061--T1
  • Report No.: ON: DE98007343
  • Grant Number: FG03-95ER62061
  • Digital Object Identifier: https://doi.org/10.2172/639709
  • Office of Scientific & Technical Information Report Number: 639709
  • Archival Resource Key: ark:/67531/metadc698691

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 31, 1996

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  • Aug. 14, 2015, 8:43 a.m.

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  • Nov. 6, 2015, 8:03 p.m.

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[Sequencing by hybridization methods to generate large arrays of oligonucleotides]. Final technical report, report, December 31, 1996; United States. (https://digital.library.unt.edu/ark:/67531/metadc698691/: accessed April 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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