Physical measurements of Cu{sup 2+}-complexes of bilirubin

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Copper is known to form complexes with bilirubin (H{sub 2}BR). Such complexes have received increased attention due to their clinical significance as free-radical scavengers. The purpose of this study was to examine a series of Cu{sup 2+}BR complexes to ascertain the nature of the binding between Cu{sup 2+} and BR. Several physical measurements of the salts were made, such as Fourier Transform Infrared (FT-IR), Fourier Transform Raman spectroscopy (FT-R), and Electron Paramagnetic Resonance (EPR). The complexes were prepared by dissolving protonated BR in NaOH, and adding different ratios of aqueous CuCl{sub 2}. At ratios of Cu{sup 2+}:H{sub 2}BR of 1:1 ... continued below

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21 p.

Creation Information

Ferraro, J.R.; Wu, J.G.; Li, W.H.; Xu, Y.Z.; Xu, D.F.; Shen, G.R. et al. December 31, 1995.

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Description

Copper is known to form complexes with bilirubin (H{sub 2}BR). Such complexes have received increased attention due to their clinical significance as free-radical scavengers. The purpose of this study was to examine a series of Cu{sup 2+}BR complexes to ascertain the nature of the binding between Cu{sup 2+} and BR. Several physical measurements of the salts were made, such as Fourier Transform Infrared (FT-IR), Fourier Transform Raman spectroscopy (FT-R), and Electron Paramagnetic Resonance (EPR). The complexes were prepared by dissolving protonated BR in NaOH, and adding different ratios of aqueous CuCl{sub 2}. At ratios of Cu{sup 2+}:H{sub 2}BR of 1:1 and 2:1, soluble complexes were formed. In solution EPR spectra demonstrated 9 hyperfine peaks, which from the splitting, is indicative of Cu{sup 2+} coordinated to 4 nitrogen atoms coming from 2 molecules of BR.

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21 p.

Notes

OSTI as DE97007861

Source

  • International Bilirubin workshop, Trieste (Italy), 6-8 Apr 1995

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  • Other: DE97007861
  • Report No.: ANL/CHM/PP--88133
  • Report No.: CONF-9504291--1
  • Grant Number: W-31109-ENG-38
  • DOI: 10.2172/505332 | External Link
  • Office of Scientific & Technical Information Report Number: 505332
  • Archival Resource Key: ark:/67531/metadc697338

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  • December 31, 1995

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  • Aug. 14, 2015, 8:43 a.m.

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  • Dec. 15, 2015, 12:07 p.m.

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Ferraro, J.R.; Wu, J.G.; Li, W.H.; Xu, Y.Z.; Xu, D.F.; Shen, G.R. et al. Physical measurements of Cu{sup 2+}-complexes of bilirubin, report, December 31, 1995; Illinois. (digital.library.unt.edu/ark:/67531/metadc697338/: accessed August 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.