Overview of PSB track on gene structure identification in large-scale genomic sequence

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The recent funding of more than a dozen major genome centers to begin community-wide high-throughput sequencing of the human genome has created a significant new challenge for the computational analysis of DNA sequence and the prediction of gene structure and function. It has been estimated that on average from 1996 to 2003, approximately 2 million bases of newly finished DNA sequence will be produced every day and be made available on the Internet and in central databases. The finished (fully assembled) sequence generated each day will represent approximately 75 new genes (and their respective proteins), and many times this number ... continued below

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4 p.

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Uberbacher, E. C. & Xu, Y. 1998.

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Description

The recent funding of more than a dozen major genome centers to begin community-wide high-throughput sequencing of the human genome has created a significant new challenge for the computational analysis of DNA sequence and the prediction of gene structure and function. It has been estimated that on average from 1996 to 2003, approximately 2 million bases of newly finished DNA sequence will be produced every day and be made available on the Internet and in central databases. The finished (fully assembled) sequence generated each day will represent approximately 75 new genes (and their respective proteins), and many times this number will be represented in partially completed sequences. The information contained in these is of immeasurable value to medical research, biotechnology, the pharmaceutical industry and researchers in a host of fields ranging from microorganism metabolism, to structural biology, to bioremediation. Sequencing of microorganisms and other model organisms is also ramping up at a very rapid rate. The genomes for yeast and several microorganisms such as H. influenza have recently been fully sequenced, although the significance of many genes remains to be determined.

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4 p.

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OSTI as DE98000576

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  • 3. Pacific symposium on biocomputing, Kapalua, HI (United States), 5 Jan 1998

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  • Other: DE98000576
  • Report No.: ORNL/CP--94807
  • Report No.: CONF-980118--
  • Grant Number: AC05-96OR22464
  • Office of Scientific & Technical Information Report Number: 563242
  • Archival Resource Key: ark:/67531/metadc696379

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • 1998

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  • Aug. 14, 2015, 8:43 a.m.

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  • May 2, 2016, 4 p.m.

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Uberbacher, E. C. & Xu, Y. Overview of PSB track on gene structure identification in large-scale genomic sequence, article, 1998; Tennessee. (digital.library.unt.edu/ark:/67531/metadc696379/: accessed October 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.