The status of low dose rate and future of high dose rate Cf-252 brachytherapy

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This work describes the current status of the US low dose rate (LDR) Cf-252 brachytherapy program. The efforts undertaken towards development of a high dose rate (HDR) remotely after loaded Cf-252 source, which can accommodate 1 mg or greater Cf-252, are also described. This HDR effort is a collaboration between Oak Ridge National Laboratory (ORNL), commercial remote after loader manufactures, the Gershenson Radiation Oncology Center (ROC), and Wayne State University. To achieve this goal, several advances in isotope chemistry and source preparation at ORNL must be achieved to yield a specific material source loading of greater than or equal 1 ... continued below

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11 p.

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Rivard, M. J.; Wierzbicki, J. G.; Van den Heuvel, F.; Chuba, P. J.; Fontanesi, J.; Martin, R. C. et al. December 1997.

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Description

This work describes the current status of the US low dose rate (LDR) Cf-252 brachytherapy program. The efforts undertaken towards development of a high dose rate (HDR) remotely after loaded Cf-252 source, which can accommodate 1 mg or greater Cf-252, are also described. This HDR effort is a collaboration between Oak Ridge National Laboratory (ORNL), commercial remote after loader manufactures, the Gershenson Radiation Oncology Center (ROC), and Wayne State University. To achieve this goal, several advances in isotope chemistry and source preparation at ORNL must be achieved to yield a specific material source loading of greater than or equal 1 mg Cf-252 per mm3. Development work with both radioactive and non-radioactive stand-ins for Cf-252 have indicated the feasibility of fabricating such sources. As a result, the decreased catheter diameter and computer controlled source placement will permit additional sites (e.g. brain, breast, prostate, lung, parotid, etc.) to be treated effectively with Cf-252 sources. Additional work at the Radiochemical Engineering and Development Center (REDC) remains in source fabrication, after loader modification, and safe design. The current LDR Cf-252 Treatment Suite at the ROC is shielded and licensed to hold up to 1 mg of Cf-252. This was designed to maintain cumulative personnel exposure, both external to the room and in direct isotope handling, at less than 20 microSv/hr. However, cumulative exposure may be greatly decreased if a Cf-252 HDR unit is employed which would eliminate direct isotope handling and decrease treatment times from tilde 3 hours to an expected range of 3 to 15 minutes. Such a Cf-252 HDR source will also demonstrate improved dose distributions over current LDR treatments due to the ability to step the point-like source throughout the target volume and weight the dwell time accordingly.

Physical Description

11 p.

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INIS; OSTI as DE98003162

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  • Radiation protection and shielding topical meeting: technologies for the new century, Nashville, TN (United States), 19-23 Apr 1998

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  • Other: DE98003162
  • Report No.: ORNL/CP--95959
  • Report No.: CONF-980403--
  • Grant Number: AC05-96OR22464
  • DOI: 10.2172/642691 | External Link
  • Office of Scientific & Technical Information Report Number: 642691
  • Archival Resource Key: ark:/67531/metadc695840

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  • December 1997

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  • Aug. 14, 2015, 8:43 a.m.

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  • Jan. 25, 2016, 4:26 p.m.

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Rivard, M. J.; Wierzbicki, J. G.; Van den Heuvel, F.; Chuba, P. J.; Fontanesi, J.; Martin, R. C. et al. The status of low dose rate and future of high dose rate Cf-252 brachytherapy, report, December 1997; Tennessee. (digital.library.unt.edu/ark:/67531/metadc695840/: accessed August 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.