Stable isotope labeling of oligosaccharide cell surface antigens

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Description

The overall goal of this Laboratory Directed Research and Development (LDRD) project was to develop new methods for synthesis of {sup 13}C-labeled oligosaccharides that are required for nuclear magnetic resonance (NMR) studies of their solution conformation. Oligosaccharides are components of the cell`s outer surface and are involved in important processes such as cell-cell recognition and adhesion. Recently, Danishefsky and coworkers at Slone-Kettering Cancer Center developed a method for the solid-phase chemical synthesis of oligosaccharides. The specific goal of this LDRD project was to prepare uniform {sup 13}C-labeled aldohexose precursors required for the solid-phase synthesis of the Lewis blood-group antigenic determinants. ... continued below

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7 p.

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Unkefer, C.J.; Silks, L.A. III & Martinez, R.A. December 31, 1998.

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Description

The overall goal of this Laboratory Directed Research and Development (LDRD) project was to develop new methods for synthesis of {sup 13}C-labeled oligosaccharides that are required for nuclear magnetic resonance (NMR) studies of their solution conformation. Oligosaccharides are components of the cell`s outer surface and are involved in important processes such as cell-cell recognition and adhesion. Recently, Danishefsky and coworkers at Slone-Kettering Cancer Center developed a method for the solid-phase chemical synthesis of oligosaccharides. The specific goal of this LDRD project was to prepare uniform {sup 13}C-labeled aldohexose precursors required for the solid-phase synthesis of the Lewis blood-group antigenic determinants. We report the synthesis of {sup 13}C-labeled D-glucal, D-galactal and Fucosyl precursors. We have been collaborating with the Danishefsky group on the synthesis of the Lewis oligosaccharides and the NMR analysis of their solution conformation.

Physical Description

7 p.

Notes

OSTI as DE98001617

Source

  • Other Information: PBD: [1998]

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  • Other: DE98001617
  • Report No.: LA-UR--97-3611
  • Grant Number: W-7405-ENG-36
  • DOI: 10.2172/562619 | External Link
  • Office of Scientific & Technical Information Report Number: 562619
  • Archival Resource Key: ark:/67531/metadc693261

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  • December 31, 1998

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  • Aug. 14, 2015, 8:43 a.m.

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  • May 20, 2016, 1:52 p.m.

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Unkefer, C.J.; Silks, L.A. III & Martinez, R.A. Stable isotope labeling of oligosaccharide cell surface antigens, report, December 31, 1998; New Mexico. (digital.library.unt.edu/ark:/67531/metadc693261/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.