Structural biology of disease-associated repetitive DNA sequences and protein-DNA complexes involved in DNA damage and repair

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Description

This project is aimed at formulating the sequence-structure-function correlations of various microsatellites in the human (and other eukaryotic) genomes. Here the authors have been able to develop and apply structure biology tools to understand the following: the molecular mechanism of length polymorphism microsatellites; the molecular mechanism by which the microsatellites in the noncoding regions alter the regulation of the associated gene; and finally, the molecular mechanism by which the expansion of these microsatellites impairs gene expression and causes the disease. Their multidisciplinary structural biology approach is quantitative and can be applied to all coding and noncoding DNA sequences associated with ... continued below

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9 p.

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Gupta, G.; Santhana Mariappan, S.V.; Chen, X.; Catasti, P.; Silks, L.A. III; Moyzis, R.K. et al. July 1, 1997.

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Description

This project is aimed at formulating the sequence-structure-function correlations of various microsatellites in the human (and other eukaryotic) genomes. Here the authors have been able to develop and apply structure biology tools to understand the following: the molecular mechanism of length polymorphism microsatellites; the molecular mechanism by which the microsatellites in the noncoding regions alter the regulation of the associated gene; and finally, the molecular mechanism by which the expansion of these microsatellites impairs gene expression and causes the disease. Their multidisciplinary structural biology approach is quantitative and can be applied to all coding and noncoding DNA sequences associated with any gene. Both NIH and DOE are interested in developing quantitative tools for understanding the function of various human genes for prevention against diseases caused by genetic and environmental effects.

Physical Description

9 p.

Notes

OSTI as DE97007838

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  • Other Information: PBD: [1997]

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  • Other: DE97007838
  • Report No.: LA-UR--97-1518
  • Grant Number: W-7405-ENG-36
  • DOI: 10.2172/505319 | External Link
  • Office of Scientific & Technical Information Report Number: 505319
  • Archival Resource Key: ark:/67531/metadc692782

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  • July 1, 1997

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  • Aug. 14, 2015, 8:43 a.m.

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  • May 20, 2016, 1:53 p.m.

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Gupta, G.; Santhana Mariappan, S.V.; Chen, X.; Catasti, P.; Silks, L.A. III; Moyzis, R.K. et al. Structural biology of disease-associated repetitive DNA sequences and protein-DNA complexes involved in DNA damage and repair, report, July 1, 1997; New Mexico. (digital.library.unt.edu/ark:/67531/metadc692782/: accessed December 15, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.