An editing environment for DNA sequence analysis and annotation

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Description

This paper presents a computer system for analyzing and annotating large-scale genomic sequences. The core of the system is a multiple-gene structure identification program, which predicts the most probable gene structures based on the given evidence, including pattern recognition, EST and protein homology information. A graphics-based user interface provides an environment which allows the user to interactively control the evidence to be used in the gene identification process. To overcome the computational bottleneck in the database similarity search used in the gene identification process, the authors have developed an effective way to partition a database into a set of sub-databases ... continued below

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9 p.

Creation Information

Uberbacher, E.C.; Xu, Y.; Shah, M.B.; Olman, V.; Parang, M. & Mural, R. December 31, 1998.

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Description

This paper presents a computer system for analyzing and annotating large-scale genomic sequences. The core of the system is a multiple-gene structure identification program, which predicts the most probable gene structures based on the given evidence, including pattern recognition, EST and protein homology information. A graphics-based user interface provides an environment which allows the user to interactively control the evidence to be used in the gene identification process. To overcome the computational bottleneck in the database similarity search used in the gene identification process, the authors have developed an effective way to partition a database into a set of sub-databases of related sequences, and reduced the search problem on a large database to a signature identification problem and a search problem on a much smaller sub-database. This reduces the number of sequences to be searched from N to O({radical}N) on average, and hence greatly reduces the search time, where N is the number of sequences in the original database. The system provides the user with the ability to facilitate and modify the analysis and modeling in real time.

Physical Description

9 p.

Notes

OSTI as DE98000574

Source

  • 3. Pacific symposium on biocomputing, Kapalua, HI (United States), 5 Jan 1998

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  • Other: DE98000574
  • Report No.: ORNL/CP--94756
  • Report No.: CONF-980118--
  • Grant Number: AC05-96OR22464
  • DOI: 10.2172/563243 | External Link
  • Office of Scientific & Technical Information Report Number: 563243
  • Archival Resource Key: ark:/67531/metadc691682

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 31, 1998

Added to The UNT Digital Library

  • Aug. 14, 2015, 8:43 a.m.

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  • Jan. 25, 2016, 6:42 p.m.

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Uberbacher, E.C.; Xu, Y.; Shah, M.B.; Olman, V.; Parang, M. & Mural, R. An editing environment for DNA sequence analysis and annotation, report, December 31, 1998; Tennessee. (digital.library.unt.edu/ark:/67531/metadc691682/: accessed November 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.