DOE project on genome mapping and sequencing. Progress report, 1992

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These efforts on the human genome project were initiated in September, 1990, to contribute towards completion of the human genome project physical mapping effort. In the original application, the authors proposed a novel strategy for constructing a physical map of human chromosome 11, based upon techniques derived in this group and by others. The original goals were to (1) produce a set of cosmid reference clones mapped to specific sites by high resolution fluorescence in situ hybridization, (2) produce a set of associated STS sequences and PCR primers for each site, (3) isolate YAC clones corresponding to each STS and, ... continued below

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3 p.

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Evans, G.A. December 31, 1992.

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Description

These efforts on the human genome project were initiated in September, 1990, to contribute towards completion of the human genome project physical mapping effort. In the original application, the authors proposed a novel strategy for constructing a physical map of human chromosome 11, based upon techniques derived in this group and by others. The original goals were to (1) produce a set of cosmid reference clones mapped to specific sites by high resolution fluorescence in situ hybridization, (2) produce a set of associated STS sequences and PCR primers for each site, (3) isolate YAC clones corresponding to each STS and, (4) construct YAC contigs such that > 90% of the chromosome would be covered by contigs of 2 mb or greater. Since that time, and with the advent of new technology and reagents, the strategy has been modified slightly but still retains the same goals as originally proposed. The authors have added a project to produce chromosome 11-specific cDNAs and determine the map location and DNA sequence of a selected portion of them.

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3 p.

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OSTI as DE98006210

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  • Other Information: PBD: [1992]

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  • Other: DE98006210
  • Report No.: DOE/ER/60694--T4
  • Grant Number: FG03-88ER60694
  • DOI: 10.2172/639719 | External Link
  • Office of Scientific & Technical Information Report Number: 639719
  • Archival Resource Key: ark:/67531/metadc691528

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 31, 1992

Added to The UNT Digital Library

  • Aug. 14, 2015, 8:43 a.m.

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  • Nov. 5, 2015, 8:10 p.m.

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Evans, G.A. DOE project on genome mapping and sequencing. Progress report, 1992, report, December 31, 1992; United States. (digital.library.unt.edu/ark:/67531/metadc691528/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.