Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research Page: 4 of 120
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The Medical Applications and Biophysical Research
Division of the Office of Biological and Environmen-
tal Research has three major areas of responsibility:
Medical Applications (primarily nuclear medicine),
Biophysical Research (structural molecular biology,
genome instrumentation and analytical chemistry),
and the EnvironmentalManagement Science Program,
which is funded by the Department's Office of
Environmental Management. A briefstatement ofthe
scope of these programs follows this preface.
This summary book provides information on
research supported in these program areas during
Fiscal Years 1996 and 1997. The research summaries
and other information in the main section of this
publication are the most current ones available to the
division, as provided by the principal investigator.
These two years saw many changes, beginning
with the renaming of the Office from the Office of
Health and Environmental Research. The new name
is consistent with the long-standing budgetary classi-
fication of the Office's programs as the Biological and
Environmental Research Program, but does not sig-
nify a change in the scope or priorities of the Office.
Several new user facilities and experimental stations
for structural molecular biology were completed at
the Department's four synchrotron light sources,
greatly increasing the ability of these facilities to meet
the growing demand for access to them. A program
in computational structural biology, emphasizing
inverse protein folding, was initated. The redirection
ofthe analytical chemistry instrumentation (measure-
ment science) program was completed and planning
began for the redirection and recompetition of the
genome instrumentation research program.
In the medical applications component the early
clinical trials of boron neutron capture therapy were
expanded. Significant advances in the medical imag-
ing research program were reported, for applications
ranging widely from addiction to illicit drugs to
cancer therapy to cardiology. The radioisotope
development component was discontinued as a
separate subprogram due to budgetary constraints
although proposals for specific projects in this area
continue to be supported. The division is engaged in
planning the redirection of the nuclear medicine
program to reflect advances in genomics, structural
biology and other fields.
The Environmental Management Science
Program (EMSP) was initiated at the direction of
Congress in 1996 to support basic research directed at
overcoming major obstacles to the cleanup of the
nuclear weapons complex. The budget for the EMSP
is in the Office of Science and Risk Policy in the
Office of Environmental Management (EM), but the
program is jointly managed by that office and the
Office of Energy Research (ER). The Division is
responsible for the largest single element of the EMSP,
analytical chemistry and instrumentation, and, from
the start of fiscal year 1997 has had the lead responsi-
bility in ER for management of the overall program.
We hope that this publication will provide
guidance to scientists considering submitting research
proposals for financial support from this division.
The research programs and their scopes are con-
tinually evaluated and adjusted taking into account
the advances in new technology and basic research.
Thus, scientists are encouraged to contact the appro-
priate staff of this division to determine the most
current program priority and scope before submitting
a proposal. Initiatives are generally announced
through program notices in the Federal Register.
These notices and other useful information are avail-
able on the World Wide Web at:
http://www er doegov/production/ober/
Comments on this publication and suggestions
to make it more effective and useful are welcome. We
plan to publish it annually and will also post updates
of this information on our home page on a regular
This volume is largely the result of the efforts of
Sharon Betson and Matesh Varma. Their substantial
contributions are acknowledged with gratitude.
Roland F Hirsch, Acting Director
MedicalApplications & Biophysical Research Division
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Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research, report, February 1, 1998; United States. (digital.library.unt.edu/ark:/67531/metadc691416/m1/4/: accessed October 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.