Improved risk estimates for carbon tetrachloride. Project status report and technical progress report Metadata

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Title

  • Main Title Improved risk estimates for carbon tetrachloride. Project status report and technical progress report

Creator

  • Author: Benson, J.M.
    Creator Type: Personal
  • Author: Nikula, K.J.
    Creator Type: Personal
  • Author: Barr, E.B.
    Creator Type: Personal
    Creator Info: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Lovelace Respiratory Research Inst.
  • Author: Springer, D.L.
    Creator Type: Personal
  • Author: Thrall, K.D.
    Creator Type: Personal
    Creator Info: Pacific Northwest National Lab., Richland, WA (United States)

Contributor

  • Sponsor: United States. Department of Energy. Office of Environmental Restoration and Waste Management.
    Contributor Type: Organization
    Contributor Info: USDOE Office of Environmental Restoration and Waste Management, Washington, DC (United States)

Publisher

  • Name: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
    Place of Publication: United States

Date

  • Creation: 1997-09-01

Language

  • English

Description

  • Content Description: Carbon tetrachloride (CCl{sub 4}) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl{sub 4} at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl{sub 4}. Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl{sub 4} in F344/Crl rats. B6C3F{sub 1} mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl{sub 4} by rats, mice, hamsters, and man. Dose-response relationships will be determined in all these studies. This information will be used to improve the physiologically based pharmacokinetic (PBPK) model for CCl{sub 4} originally developed by Paustenbach et al. (1988) and more recently revised by Thrall and Kenny (1996). The authors will also provide scientific evidence that CCl{sub 4}, like chloroform, is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation.
  • Physical Description: 8 p.

Subject

  • Keyword: Liver
  • Keyword: Carcinogenesis
  • Keyword: Biological Models
  • Keyword: Progress Report
  • Keyword: Man
  • Keyword: Carbon Tetrachloride
  • Keyword: Dose-Response Relationships
  • STI Subject Categories: 56 Biology And Medicine, Applied Studies
  • Keyword: Metabolism

Source

  • Other Information: PBD: [1997]

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Other: DE97009333
  • Report No.: DOE/AL/76406--T1
  • Grant Number: FC04-96AL76406
  • DOI: 10.2172/532505
  • Office of Scientific & Technical Information Report Number: 532505
  • Archival Resource Key: ark:/67531/metadc691277

Note

  • Display Note: OSTI as DE97009333