Improved risk estimates for carbon tetrachloride. Project status report and technical progress report

Thumbnail image of item number 1 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 2 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 3 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 4 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Showing 1-4 of 8 pages in this report.

PDF Version Also Available for Download.

Description

Carbon tetrachloride (CCl{sub 4}) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl{sub 4} at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl{sub 4}. Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl{sub 4} in F344/Crl rats. B6C3F{sub 1} mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl{sub 4} by rats, mice, ... continued below

Physical Description

8 p.

Creation Information

Benson, J.M.; Nikula, K.J.; Barr, E.B.; Springer, D.L. & Thrall, K.D. September 1, 1997.

Context

This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 58 times , with 11 in the last month . More information about this report can be viewed below.

Who

People and organizations associated with either the creation of this report or its content.

Authors

Sponsor

Publisher

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

About | Browse this Partner

Contact Us

Corrections Questions

What

Descriptive information to help identify this report. Follow the links below to find similar items on the Digital Library.

Description

Carbon tetrachloride (CCl{sub 4}) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl{sub 4} at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl{sub 4}. Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl{sub 4} in F344/Crl rats. B6C3F{sub 1} mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl{sub 4} by rats, mice, hamsters, and man. Dose-response relationships will be determined in all these studies. This information will be used to improve the physiologically based pharmacokinetic (PBPK) model for CCl{sub 4} originally developed by Paustenbach et al. (1988) and more recently revised by Thrall and Kenny (1996). The authors will also provide scientific evidence that CCl{sub 4}, like chloroform, is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation.

Physical Description

8 p.

Notes

OSTI as DE97009333

Source

  • Other Information: PBD: [1997]

Language

Item Type

Identifier

Unique identifying numbers for this report in the Digital Library or other systems.

  • Other: DE97009333
  • Report No.: DOE/AL/76406--T1
  • Grant Number: FC04-96AL76406
  • DOI: 10.2172/532505 | External Link
  • Office of Scientific & Technical Information Report Number: 532505
  • Archival Resource Key: ark:/67531/metadc691277

Collections

This report is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

About | Browse this Collection

What responsibilities do I have when using this report?

Digital Files

When

Dates and time periods associated with this report.

Creation Date

  • September 1, 1997

Added to The UNT Digital Library

  • Aug. 14, 2015, 8:43 a.m.

Description Last Updated

  • June 14, 2016, 5:57 p.m.

Usage Statistics

When was this report last used?

Yesterday: 0
Past 30 days: 11
Total Uses: 58
More Statistics

Interact With This Report

Here are some suggestions for what to do next.

Start Reading

Thumbnail image of item number 1 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 2 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 3 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.
Thumbnail image of item number 4 in: 'Improved risk estimates for carbon tetrachloride. Project status report and technical progress report'.

PDF Version Also Available for Download.

Citations, Rights, Re-Use

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Benson, J.M.; Nikula, K.J.; Barr, E.B.; Springer, D.L. & Thrall, K.D. Improved risk estimates for carbon tetrachloride. Project status report and technical progress report, report, September 1, 1997; United States. (digital.library.unt.edu/ark:/67531/metadc691277/: accessed September 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.