Atlas of experimentally-induced neoplasia in beagle dogs

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Description

Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy`s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid ... continued below

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172 p.

Creation Information

Dagle, G.E. & Watson, C.R. October 1, 1996.

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Description

Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy`s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid tissues, mammary gland, pituitary, testis, and thyroid. To provide further assurance of cooperation among the DOE laboratories involved, DOE organized several Task Groups in 1985, composed of staff members from the laboratories. The Task Group on Biological Effects was asked to standardize nomenclature and diagnostic criteria for pathology; this beagle pathology atlas is the result of that request. The atlas describes target organs of particular interest: lungs for radionuclides delivered by inhalation; bones for bone-seeking radionuclides; and hematopoietic and other soft tissues for external irradiation.

Physical Description

172 p.

Notes

INIS; OSTI as DE97053519

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  • Other Information: PBD: Oct 1996

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  • Other: DE97053519
  • Report No.: PNNL--11358
  • Grant Number: AC06-76RL01830
  • DOI: 10.2172/555438 | External Link
  • Office of Scientific & Technical Information Report Number: 555438
  • Archival Resource Key: ark:/67531/metadc690594

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • October 1, 1996

Added to The UNT Digital Library

  • Aug. 14, 2015, 8:43 a.m.

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  • April 6, 2016, 1:43 p.m.

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Dagle, G.E. & Watson, C.R. Atlas of experimentally-induced neoplasia in beagle dogs, report, October 1, 1996; Richland, Washington. (digital.library.unt.edu/ark:/67531/metadc690594/: accessed October 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.