Evaluation of boronated EGF as a potential delivery agent for BNCT of brain tumors

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The epidermal growth factor receptor (EGFR) gene is often amplified in human glioblastomas, but, reflecting the cellular heterogeneity of these tumors, the frequency of amplification is variable. Since the number of EGFR has been considered as a potential target for the specific delivery of diagnostic and therapeutic agents to brain tumors. Initially, the focus was on using anti-EGFR monoclonal antibodies or their fragments, but within the past few years there has been increasing interest in using EGF based bioconjugates as targeting agents. Recently, we have described a method for the boronation of EGF and have characterized the resulting bioconjugates in ... continued below

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Yang, Weilian; Barth, R.F. & Adams, D.M. December 31, 1996.

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The epidermal growth factor receptor (EGFR) gene is often amplified in human glioblastomas, but, reflecting the cellular heterogeneity of these tumors, the frequency of amplification is variable. Since the number of EGFR has been considered as a potential target for the specific delivery of diagnostic and therapeutic agents to brain tumors. Initially, the focus was on using anti-EGFR monoclonal antibodies or their fragments, but within the past few years there has been increasing interest in using EGF based bioconjugates as targeting agents. Recently, we have described a method for the boronation of EGF and have characterized the resulting bioconjugates in vitro. In the present study, we have investigated the potential usefulness of boronated EGF as a delivery agent for neutron capture therapy in rats bearing intracerebral implants of the C6 glioma, which has been transfected with the gene encoding EGFR. Our results indicate that following intratumoral injection, boronated EGF selectivity targeted the transfected EGFR positive C6 glioma, and that the amount of delivered to the tumor exceeded by 3-4 orders of magnitude that which could be delivered by intravenous injection.

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5 p.

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OSTI as DE97008897

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  • 7. international symposium on neutron capture therapy for cancer, Zurich (Switzerland), 4-7 Sep 1996

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  • Other: DE97008897
  • Report No.: BNL--64623
  • Report No.: CONF-9609293--
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 539879
  • Archival Resource Key: ark:/67531/metadc689689

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Office of Scientific & Technical Information Technical Reports

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  • December 31, 1996

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  • Aug. 14, 2015, 8:43 a.m.

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  • Nov. 9, 2015, 9:46 p.m.

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Yang, Weilian; Barth, R.F. & Adams, D.M. Evaluation of boronated EGF as a potential delivery agent for BNCT of brain tumors, article, December 31, 1996; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc689689/: accessed June 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.