Microdosimetric investigations at the fast neutron therapy facility at Fermilab

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Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} ... continued below

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Medium: P; Size: 94 pages

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Langen, K.M. December 1, 1997.

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Description

Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.

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Medium: P; Size: 94 pages

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INIS; OSTI as DE00003483

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  • Other Information: Thesis (Ph.D.)

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  • Report No.: DOE/CH/03000--T28
  • Grant Number: AC02-76CH03000
  • DOI: 10.2172/3483 | External Link
  • Office of Scientific & Technical Information Report Number: 3483
  • Archival Resource Key: ark:/67531/metadc689090

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 1, 1997

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Nov. 3, 2015, 2:29 p.m.

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Langen, K.M. Microdosimetric investigations at the fast neutron therapy facility at Fermilab, report, December 1, 1997; United States. (digital.library.unt.edu/ark:/67531/metadc689090/: accessed December 15, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.