Ultrasensitive nucleic acid sequence detection by single-molecule electrophoresis

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Description

This is the final report of a one-year laboratory-directed research and development project at Los Alamos National Laboratory. There has been considerable interest in the development of very sensitive clinical diagnostic techniques over the last few years. Many pathogenic agents are often present in extremely small concentrations in clinical samples, especially at the initial stages of infection, making their detection very difficult. This project sought to develop a new technique for the detection and accurate quantification of specific bacterial and viral nucleic acid sequences in clinical samples. The scheme involved the use of novel hybridization probes for the detection of ... continued below

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6 p.

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Castro, A & Shera, E.B. September 1, 1996.

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Description

This is the final report of a one-year laboratory-directed research and development project at Los Alamos National Laboratory. There has been considerable interest in the development of very sensitive clinical diagnostic techniques over the last few years. Many pathogenic agents are often present in extremely small concentrations in clinical samples, especially at the initial stages of infection, making their detection very difficult. This project sought to develop a new technique for the detection and accurate quantification of specific bacterial and viral nucleic acid sequences in clinical samples. The scheme involved the use of novel hybridization probes for the detection of nucleic acids combined with our recently developed technique of single-molecule electrophoresis. This project is directly relevant to the DOE`s Defense Programs strategic directions in the area of biological warfare counter-proliferation.

Physical Description

6 p.

Notes

OSTI as DE96014721

Source

  • Other Information: PBD: [1996]

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  • Other: DE96014721
  • Report No.: LA-UR--96-3052
  • Grant Number: W-7405-ENG-36
  • DOI: 10.2172/374265 | External Link
  • Office of Scientific & Technical Information Report Number: 374265
  • Archival Resource Key: ark:/67531/metadc688772

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Creation Date

  • September 1, 1996

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • March 10, 2016, 1:43 p.m.

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Castro, A & Shera, E.B. Ultrasensitive nucleic acid sequence detection by single-molecule electrophoresis, report, September 1, 1996; New Mexico. (digital.library.unt.edu/ark:/67531/metadc688772/: accessed August 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.