BPA uptake in rat tissues after partial hepatectomy

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In boron neutron capture therapy (BNCT), boron given as boronophenylalanine (BPA) accumulates transiently not only in tumors but also in normal tissues. Average boron concentrations in transplanted 9L gliosarcoma tumors of 20 rats were 2.5 to 3.7 times concentrations found in blood. Although boron levels in a variety of tissues were also higher than blood the concentrations were less than the lowest found in the tumor. Further note than although BPA is a structural analogue of phenylalanine (Phe), the pathway of BPA uptake into regenerating liver may not be linked to Phe uptake mechanisms.

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11 p.

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Slatkin, D.N.; Nawrocky, M.M.; Coderre, J.A.; Fisher, C.D.; Joel, D.D.; Lombardo, D.T. et al. December 31, 1996.

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Description

In boron neutron capture therapy (BNCT), boron given as boronophenylalanine (BPA) accumulates transiently not only in tumors but also in normal tissues. Average boron concentrations in transplanted 9L gliosarcoma tumors of 20 rats were 2.5 to 3.7 times concentrations found in blood. Although boron levels in a variety of tissues were also higher than blood the concentrations were less than the lowest found in the tumor. Further note than although BPA is a structural analogue of phenylalanine (Phe), the pathway of BPA uptake into regenerating liver may not be linked to Phe uptake mechanisms.

Physical Description

11 p.

Notes

OSTI as DE97000978

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  • 7. international symposium on neutron capture therapy for cancer, Zurich (Switzerland), 4-7 Sep 1996

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  • Other: DE97000978
  • Report No.: BNL--63610
  • Report No.: CONF-9609293--2
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 434935
  • Archival Resource Key: ark:/67531/metadc688625

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  • December 31, 1996

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  • July 25, 2015, 2:20 a.m.

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  • Nov. 6, 2015, 10:54 p.m.

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Slatkin, D.N.; Nawrocky, M.M.; Coderre, J.A.; Fisher, C.D.; Joel, D.D.; Lombardo, D.T. et al. BPA uptake in rat tissues after partial hepatectomy, article, December 31, 1996; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc688625/: accessed September 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.