Enzyme catalysts for a biotechnology-based chemical industry. Final report, September 29, 1993--September 28, 1998

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Enzymes have enormous potential for reducing energy requirements and environmental problems in the chemicals and pharmaceutical industries. The explosion of tools that has come out of molecular biology during the last 20 years has made it possible to evolve enzymes for features never required in nature. Scientists can speed up the rate and channel the direction of evolution by controlling mutagenesis and the accompanying selection pressures. Darwinian evolution carried out in the test tube offers a unique opportunity for biotechnology: the ability to tailor enzymes for optimal performance in a wide range of applications. Thus it is possible, for example, ... continued below

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7 p.

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Arnold, F.H. November 16, 1998.

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Enzymes have enormous potential for reducing energy requirements and environmental problems in the chemicals and pharmaceutical industries. The explosion of tools that has come out of molecular biology during the last 20 years has made it possible to evolve enzymes for features never required in nature. Scientists can speed up the rate and channel the direction of evolution by controlling mutagenesis and the accompanying selection pressures. Darwinian evolution carried out in the test tube offers a unique opportunity for biotechnology: the ability to tailor enzymes for optimal performance in a wide range of applications. Thus it is possible, for example, to evolve enzymes that carry out reactions on nonnatural substrates or even to carry out reactions for which there is no counterpart in nature. Due to the vast size of the potential sequence space, however, explorations by directed evolution must be guided by sound principles and workable strategies. During the course of this group, this laboratory has continued to make significant progress in the evolution of industrial enzymes as well as in developing general methods for in vitro evolution.

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7 p.

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OSTI as DE99002094

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  • Other Information: PBD: 16 Nov 1998

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  • Other: DE99002094
  • Report No.: DOE/CH/10578--T5
  • Grant Number: FG36-93CH10578
  • DOI: 10.2172/345021 | External Link
  • Office of Scientific & Technical Information Report Number: 345021
  • Archival Resource Key: ark:/67531/metadc688377

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  • November 16, 1998

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  • July 25, 2015, 2:20 a.m.

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  • Feb. 20, 2017, 3:55 p.m.

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Arnold, F.H. Enzyme catalysts for a biotechnology-based chemical industry. Final report, September 29, 1993--September 28, 1998, report, November 16, 1998; Pasadena, California. (digital.library.unt.edu/ark:/67531/metadc688377/: accessed November 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.