Low doses of ionizing radiation to mammalian cells may rather control than cause DNA damage

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This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced metabolic changes that induce mechanisms of DNA damage mitigation, which do not operate at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in the ... continued below

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18 p.

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Feinendegen, L.E.; Bond, V.P.; Sondhaus, C.A. & Altman, K.I. December 31, 1998.

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  • Feinendegen, L.E. Brookhaven National Lab., Upton, NY (United States). Medical Dept.
  • Bond, V.P. Washington State Univ., Richland, WA (United States)
  • Sondhaus, C.A. Univ. of Arizona, Tucson, AZ (United States). Dept. of Radiology and Radiation Control Office
  • Altman, K.I. Univ. of Rochester Medical Center, NY (United States). Dept. of Biochemistry and Biophysics

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Description

This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced metabolic changes that induce mechanisms of DNA damage mitigation, which do not operate at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in the low-dose region. This suggests that the LNT hypothesis should be reexamined. This paper aims at demonstrating tissue effects as an expression of cellular responses, both damaging and defensive, in relation to the energy deposited in cell mass, by use of microdosimetric concepts.

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18 p.

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INIS; OSTI as DE99001520

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  • DNA damage and repair conference, Shillon (India), 7-10 Apr 1998

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  • Other: DE99001520
  • Report No.: BNL--65902
  • Report No.: CONF-9804105--
  • Grant Number: AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 307994
  • Archival Resource Key: ark:/67531/metadc687877

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 31, 1998

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Nov. 5, 2015, 12:35 p.m.

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Feinendegen, L.E.; Bond, V.P.; Sondhaus, C.A. & Altman, K.I. Low doses of ionizing radiation to mammalian cells may rather control than cause DNA damage, article, December 31, 1998; United States. (digital.library.unt.edu/ark:/67531/metadc687877/: accessed November 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.