Frequency doubling and tripling of ultrashort laser pulses in biological tissues

PDF Version Also Available for Download.

Description

Structural proteins such as collagen and elastin are known to generate second harmonic at high laser intensities. Second and third harmonic generations (SHG, THG) of 0.4 ps Ti-Sapphire laser radiation at 800 nm were observed in various biological tissues. Dependence of SHG on laser pulse energy and pulse width was investigated. Reflected second harmonic yield was measured for animal tissue <i>in vitro</i> and human skin <i>in vivo</i>. The yield varies about a factor of 20 for various areas of the skin while the scattered laser radiation (diffuse reflectance) varies only by a factor of 2. In some cases the THG ... continued below

Physical Description

576 Kilobytes

Creation Information

Da Silva, L. B.; Eichler, J.; Joslin, E. J. & Kim, B.-M. July 24, 1998.

Context

This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Publisher

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Description

Structural proteins such as collagen and elastin are known to generate second harmonic at high laser intensities. Second and third harmonic generations (SHG, THG) of 0.4 ps Ti-Sapphire laser radiation at 800 nm were observed in various biological tissues. Dependence of SHG on laser pulse energy and pulse width was investigated. Reflected second harmonic yield was measured for animal tissue <i>in vitro</i> and human skin <i>in vivo</i>. The yield varies about a factor of 20 for various areas of the skin while the scattered laser radiation (diffuse reflectance) varies only by a factor of 2. In some cases the THG efficiency was comparable to the SHG. Possible applications of higher harmonic radiation for diagnostics and microscopy are discussed.

Physical Description

576 Kilobytes

Subjects

Source

  • Nonlinear Optics '98, Kauai, HI, August 10-14, 1998

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

  • Other: DE00003518
  • Report No.: UCRL-JC-131504
  • Grant Number: W-7405-Eng-48
  • Office of Scientific & Technical Information Report Number: 3518
  • Archival Resource Key: ark:/67531/metadc686807

Collections

This article is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • July 24, 1998

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

Description Last Updated

  • May 6, 2016, 11:19 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 1
Total Uses: 4

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

Citations, Rights, Re-Use

Da Silva, L. B.; Eichler, J.; Joslin, E. J. & Kim, B.-M. Frequency doubling and tripling of ultrashort laser pulses in biological tissues, article, July 24, 1998; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc686807/: accessed November 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.