Inflammatory bowel disease gene discovery. CRADA final report

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Description

The ultimate goal of this project is to identify the human gene(s) responsible for the disorder known as IBD. The work was planned in two phases. The desired products resulting from Phase 1 were BAC clone(s) containing the genetic marker(s) identified by gene/Networks, Inc. as potentially linked to IBD, plasmid subclones of those BAC(s), and new genetic markers developed from these plasmid subclones. The newly developed markers would be genotyped by gene/Networks, Inc. to ascertain evidence for linkage or non-linkage of IBD to this region. If non-linkage was indicated, the project would move to investigation of other candidate chromosomal regions. ... continued below

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3 p.

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Creator: Unknown. September 9, 1997.

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Description

The ultimate goal of this project is to identify the human gene(s) responsible for the disorder known as IBD. The work was planned in two phases. The desired products resulting from Phase 1 were BAC clone(s) containing the genetic marker(s) identified by gene/Networks, Inc. as potentially linked to IBD, plasmid subclones of those BAC(s), and new genetic markers developed from these plasmid subclones. The newly developed markers would be genotyped by gene/Networks, Inc. to ascertain evidence for linkage or non-linkage of IBD to this region. If non-linkage was indicated, the project would move to investigation of other candidate chromosomal regions. Where linkage was indicated, the project would move to Phase 2, in which a physical map of the candidate region(s) would be developed. The products of this phase would be contig(s) of BAC clones in the region exhibiting linkage to IBD, as well as plasmic subclones of the BACs and further genetic marker development. There would also be continued genotyping with new polymorphic markers during this phase. It was anticipated that clones identified and developed during these two phases would provide the physical resources for eventual disease gene discovery.

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3 p.

Notes

OSTI as DE99001313

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  • Other Information: PBD: 9 Sep 1997

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  • Other: DE99001313
  • Report No.: LLNL--99001313
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/296882 | External Link
  • Office of Scientific & Technical Information Report Number: 296882
  • Archival Resource Key: ark:/67531/metadc686697

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Creation Date

  • September 9, 1997

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Feb. 16, 2016, 8:07 p.m.

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Inflammatory bowel disease gene discovery. CRADA final report, report, September 9, 1997; California. (digital.library.unt.edu/ark:/67531/metadc686697/: accessed September 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.