Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

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The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, ... continued below

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31 p.

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Adelstein, S.J. February 1, 1995.

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  • Adelstein, S.J. Massachusetts Inst. of Tech., Cambridge, MA (United States). Office of Sponsored Programs

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Description

The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors` 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy.

Physical Description

31 p.

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INIS; OSTI as DE95009691

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  • Other Information: PBD: Feb 1995

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  • Other: DE95009691
  • Report No.: DOE/ER/60460--T4
  • Grant Number: FG02-86ER60460;FG02-87ER60526
  • DOI: 10.2172/41285 | External Link
  • Office of Scientific & Technical Information Report Number: 41285
  • Archival Resource Key: ark:/67531/metadc686519

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • February 1, 1995

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Feb. 20, 2017, 1:48 p.m.

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Adelstein, S.J. Harvard-MIT research program in short-lived radiopharmaceuticals. Final report, report, February 1, 1995; Cambridge, Massachusetts. (digital.library.unt.edu/ark:/67531/metadc686519/: accessed October 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.