Visualization of monoamine oxidase in human brain

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Monoamine oxidase is a flavin enzyme which exists in two subtypes, MAO A and MAO B. In human brain MAO B predominates and is largely compartmentalized in cell bodies of serotonergic neurons and glia. Regional distribution of MAO B was determined by positron computed tomography with volunteers after the administration of deuterium substituted [11C]L-deprenyl. The basal ganglia and thalamus exhibited the greatest concentrations of MAO B with intermediate levels in the frontal cortex and cingulate gyrus while lowest levels were observed in the parietal and temporal cortices and cerebellum. We observed that brain MAO B increases with are in health ... continued below

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5 p.

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Fowler, J.S.; Volkow, N.D.; Wang, G.J.; Pappas, N.; Shea, C.; MacGregor, R.R. et al. December 31, 1996.

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Monoamine oxidase is a flavin enzyme which exists in two subtypes, MAO A and MAO B. In human brain MAO B predominates and is largely compartmentalized in cell bodies of serotonergic neurons and glia. Regional distribution of MAO B was determined by positron computed tomography with volunteers after the administration of deuterium substituted [11C]L-deprenyl. The basal ganglia and thalamus exhibited the greatest concentrations of MAO B with intermediate levels in the frontal cortex and cingulate gyrus while lowest levels were observed in the parietal and temporal cortices and cerebellum. We observed that brain MAO B increases with are in health normal subjects, however the increases were generally smaller than those revealed with post-mortem studies.

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5 p.

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OSTI as DE97000977

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  • 8. international catecholamine symposium, Pacific Grove, CA (United States), 13-18 Oct 1996

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  • Other: DE97000977
  • Report No.: BNL--63251
  • Report No.: CONF-9610224--1
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 434949
  • Archival Resource Key: ark:/67531/metadc685359

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  • December 31, 1996

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  • July 25, 2015, 2:20 a.m.

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  • Oct. 4, 2017, 2:07 p.m.

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Fowler, J.S.; Volkow, N.D.; Wang, G.J.; Pappas, N.; Shea, C.; MacGregor, R.R. et al. Visualization of monoamine oxidase in human brain, article, December 31, 1996; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc685359/: accessed April 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.