Bone sarcoma in humans induced by radium: A threshold response?

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The radium 226 and radium 228 have induced malignancies in the skeleton (primarily bone sarcomas) of humans. They have also induced carcinomas in the paranasal sinuses and mastoid air cells. There is no evidence that any leukemias or any other solid cancers have been induced by internally deposited radium. This paper discuses a study conducted on the dial painter population. This study made a concerted effort to verify, for each of the measured radium cases, the published values of the skeletal dose and the initial intake of radium. These were derived from body content measurements made some 40 years after ... continued below

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9 p.

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Rowland, R. E. August 1996.

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Description

The radium 226 and radium 228 have induced malignancies in the skeleton (primarily bone sarcomas) of humans. They have also induced carcinomas in the paranasal sinuses and mastoid air cells. There is no evidence that any leukemias or any other solid cancers have been induced by internally deposited radium. This paper discuses a study conducted on the dial painter population. This study made a concerted effort to verify, for each of the measured radium cases, the published values of the skeletal dose and the initial intake of radium. These were derived from body content measurements made some 40 years after the radium intake. Corrections to the assumed radium retention function resulted in a considerable number of dose changes. These changes have changed the shape of the dose response function. It now appears that the induction of bone sarcomas is a threshold process.

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9 p.

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INIS; OSTI as DE96013598

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  • 27. annual meeting of the European Society for Radiation Biology, Montpellier (France), 2-4 Sep 1996

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  • Other: DE96013598
  • Report No.: ANL/ER/CP--90343
  • Report No.: CONF-9609230--1
  • Grant Number: W-31109-ENG-38
  • Office of Scientific & Technical Information Report Number: 371427
  • Archival Resource Key: ark:/67531/metadc685039

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • August 1996

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  • July 25, 2015, 2:20 a.m.

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  • Dec. 16, 2015, 4:56 p.m.

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Rowland, R. E. Bone sarcoma in humans induced by radium: A threshold response?, article, August 1996; Illinois. (digital.library.unt.edu/ark:/67531/metadc685039/: accessed December 11, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.