Simulations of laser thrombolysis

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Description

The authors have shown that bubble expansion and collapse near the interface between two materials with modest property differences produces jet-like interpenetration of the two materials. The bubble dynamics at a water-viscous fluid interface is compared with that at the interface of water with a weak elastic-plastic material. The authors find that, despite rather similar behavior during bubble growth and the initial portion of bubble collapse, the terminal jetting behavior is quite different, even in direction. The elastic-plastic properties chosen realistically represent real and surrogate thrombus. Simulations using the elastic-plastic model quantitatively agree with laboratory thrombolysis mass removal experiments. In ... continued below

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13 p.

Creation Information

Chapyak, E. J. & Godwin, R. P. March 1, 1999.

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This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this report can be viewed below.

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  • Los Alamos National Laboratory
    Publisher Info: Los Alamos National Lab., Applied Theoretical and Computational Physics Div., NM (United States)
    Place of Publication: New Mexico

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Description

The authors have shown that bubble expansion and collapse near the interface between two materials with modest property differences produces jet-like interpenetration of the two materials. The bubble dynamics at a water-viscous fluid interface is compared with that at the interface of water with a weak elastic-plastic material. The authors find that, despite rather similar behavior during bubble growth and the initial portion of bubble collapse, the terminal jetting behavior is quite different, even in direction. The elastic-plastic properties chosen realistically represent real and surrogate thrombus. Simulations using the elastic-plastic model quantitatively agree with laboratory thrombolysis mass removal experiments. In the earlier simulations of laboratory experiments, walls have been remote so as to not effect the dynamics. Here the authors present two-dimensional simulations of thrombolysis with water over elastic-plastic surrogate thrombus in a geometry representative of the clinical situation. The calculations include thin cylindrical elastic walls with properties and dimensions appropriate for arteries. The presence of these artery walls does not substantially change the interface jetting predicted in unconfined simulations.

Physical Description

13 p.

Notes

OSTI as DE99002049

Source

  • Photonics West `99: international symposium on biomedical optics (BIOS`99), San Jose, CA (United States), 23-29 Jan 1999

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  • Other: DE99002049
  • Report No.: LA-UR--99-333
  • Report No.: CONF-990110--
  • Grant Number: W-7405-ENG-36
  • DOI: 10.2172/329518 | External Link
  • Office of Scientific & Technical Information Report Number: 329518
  • Archival Resource Key: ark:/67531/metadc683884

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Creation Date

  • March 1, 1999

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

Description Last Updated

  • Nov. 3, 2016, 1:30 p.m.

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Chapyak, E. J. & Godwin, R. P. Simulations of laser thrombolysis, report, March 1, 1999; New Mexico. (digital.library.unt.edu/ark:/67531/metadc683884/: accessed September 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.