Low density lipoprotein subclasses and response to a low-fat diet in healthy men

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Lipid and lipoprotein response to reduced dietary fat intake was investigated in relation to differences in distribution of LDL subclasses among 105 healthy men consuming high-fat (46%) and low-fat (24%) diets in random order for six weeks each. On high-fat, 87 subjects had predominantly large, buoyant LDL as measured by gradient gel electrophoresis and confirmed by analytic ultracentrifugation (pattern A), while the remainder had primarily smaller, denser LDL (pattern B). On low-fat, 36 men changed from pattern A to B. Compared with the 51 men in the stable A group, men in the stable B group (n = 18) had ... continued below

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38 p.

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Krauss, R.M. & Dreon, D.M. November 1, 1994.

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Description

Lipid and lipoprotein response to reduced dietary fat intake was investigated in relation to differences in distribution of LDL subclasses among 105 healthy men consuming high-fat (46%) and low-fat (24%) diets in random order for six weeks each. On high-fat, 87 subjects had predominantly large, buoyant LDL as measured by gradient gel electrophoresis and confirmed by analytic ultracentrifugation (pattern A), while the remainder had primarily smaller, denser LDL (pattern B). On low-fat, 36 men changed from pattern A to B. Compared with the 51 men in the stable A group, men in the stable B group (n = 18) had a three-fold greater reduction in LDL cholesterol and significantly greater reductions in plasma apoB and mass of intermediate (LDL II) and small (LDL III) LDL subtractions measured by analytic ultracentrifugation. In both stable A and change groups, reductions in LDL-cholesterol were not accompanied by reduced plasma apoB, consistent with the observation of a shift in LDL particle mass from larger, lipid-enriched (LDL I and II) to smaller, lipid-depleted (LDL III and IV) subfractions, without significant change in particle number. Genetic and environmental factors influencing LDL subclass distributions thus may also contribute substantially to interindividual variation in response to a low-fat diet.

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38 p.

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OSTI as DE95008497

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  • Federation of Americal Societies for Experimental Biology (FASEB) symposium, Anaheim, CA (United States), 24-28 Apr 1994

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  • Other: DE95008497
  • Report No.: LBL--36333
  • Report No.: CONF-9404251--1
  • Grant Number: AC03-76SF00098
  • DOI: 10.2172/41265 | External Link
  • Office of Scientific & Technical Information Report Number: 41265
  • Archival Resource Key: ark:/67531/metadc683082

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • November 1, 1994

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  • July 25, 2015, 2:20 a.m.

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  • June 24, 2016, 6:25 p.m.

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Krauss, R.M. & Dreon, D.M. Low density lipoprotein subclasses and response to a low-fat diet in healthy men, report, November 1, 1994; California. (digital.library.unt.edu/ark:/67531/metadc683082/: accessed June 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.