Protecting effects specifically from low doses of ionizing radiation to mammalian cells challenge the concept of linearity

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This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced changes in intracellular signaling that induce mechanisms of DNA damage control different from those operating at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity ... continued below

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29 p.

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Feinendegen, L.E.; Bond, V.P.; Sondhaus, C.A. & Altman, K.I. December 31, 1998.

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  • Feinendegen, L.E. Brookhaven National Lab., Upton, NY (United States). Medical Dept.
  • Bond, V.P. Washington State Univ., Richland, WA (United States)
  • Sondhaus, C.A. Univ. of Arizona, Tucson, AZ (United States). Dept. of Radiology and Radiation Control Office
  • Altman, K.I. Univ. of Rochester Medical Center, NY (United States). Dept. of Biochemistry and Biophysics

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Description

This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced changes in intracellular signaling that induce mechanisms of DNA damage control different from those operating at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in the low-dose region. This suggests that the LNT hypothesis should be reexamined. The aim of this paper is to demonstrate that by use of microdosimetric concepts, the energy deposited in cell mass can be related to the occurrence of cellular responses, both damaging and defensive.

Physical Description

29 p.

Notes

INIS; OSTI as DE99001521

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  • Conference of biological effects of low doses, Ottawa (Canada), 8 Jun 1998

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  • Other: DE99001521
  • Report No.: BNL--65903
  • Report No.: CONF-9806174--
  • Grant Number: AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 307993
  • Archival Resource Key: ark:/67531/metadc680989

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  • December 31, 1998

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  • July 25, 2015, 2:20 a.m.

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  • Nov. 5, 2015, 2:46 p.m.

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Feinendegen, L.E.; Bond, V.P.; Sondhaus, C.A. & Altman, K.I. Protecting effects specifically from low doses of ionizing radiation to mammalian cells challenge the concept of linearity, article, December 31, 1998; United States. (digital.library.unt.edu/ark:/67531/metadc680989/: accessed September 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.