A methodology for assessing the impact of mutagens on aquatic ecosystems. Final report

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Assessments of impacts of hazardous agents (i.e., chemical and physical mutagens) on human health have focused on defining the effects of chronic exposure on individuals, with cancer being the main effect of concern. In contrast, impacts on ecosystems have traditionally been gauged by the assessment of near-term organism mortality, which is clearly not a useful endpoint for assessing the long-term effects of chronic exposures. Impacts on individual organisms that affect the long-term survival of populations are much more important but are also more difficult to define. Therefore, methods that provide accurate measures of sub-lethal effects that are linked to population ... continued below

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Knezovich, J.P. & Martinelli, R.E. March 1, 1995.

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Description

Assessments of impacts of hazardous agents (i.e., chemical and physical mutagens) on human health have focused on defining the effects of chronic exposure on individuals, with cancer being the main effect of concern. In contrast, impacts on ecosystems have traditionally been gauged by the assessment of near-term organism mortality, which is clearly not a useful endpoint for assessing the long-term effects of chronic exposures. Impacts on individual organisms that affect the long-term survival of populations are much more important but are also more difficult to define. Therefore, methods that provide accurate measures of sub-lethal effects that are linked to population survival are required so that accurate assessments of environmental damage can be made and remediation efforts, if required, can be initiated. Radioactive substances have entered aquatic environments as a result of research and production activities, intentional disposal, and accidental discharges. At several DOE sites, surface waters and sediments are contaminated with radioactive and mutagenic materials. The accident at the Chernobyl power station in the former Soviet Union (FSU) has resulted in the contamination of biota present in the Kiev Reservoir. This documents presents a methodology which addresses the effects of a direct-acting mutagen (radiation) on aquantic organisms by applying sensitive techniques for assessing damage to genetic material.

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10 p.

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INIS; OSTI as DE95009044

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  • 45. annual American Institute of Biological Sciences (AIBS) meeting, Knoxville, TN (United States), 7-11 Aug 1994

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  • Other: DE95009044
  • Report No.: UCRL-JC--120466
  • Report No.: CONF-9408227--1
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 42529
  • Archival Resource Key: ark:/67531/metadc679415

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • March 1, 1995

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  • July 25, 2015, 2:20 a.m.

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  • Feb. 19, 2016, 12:05 p.m.

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Knezovich, J.P. & Martinelli, R.E. A methodology for assessing the impact of mutagens on aquatic ecosystems. Final report, article, March 1, 1995; California. (digital.library.unt.edu/ark:/67531/metadc679415/: accessed October 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.