An HSEF for murine myeloid leukemia

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In the past decade, a large amount of effort has gone into the development of hit size effectiveness functions (HSEFs), with the ultimate aim of replacing the present absorbed dose-RBE-Q system. However, the absorbed dose determined at the tissue level is incapable of providing information on single hits on (doses to) the single cell. As a result, it is necessary to resort to microdosimetry, which is capable of providing not only the number of hits on cells, but the distribution of hit sizes as well. From this information, an HSEF can be derived. However, to date there have been no ... continued below

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7 p.

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Bond, V.P.; Cronkite, E.P.; Bullis, J.E.; Wuu, C.S.; Marino, S.A. & Zaider, M. October 1, 1996.

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Description

In the past decade, a large amount of effort has gone into the development of hit size effectiveness functions (HSEFs), with the ultimate aim of replacing the present absorbed dose-RBE-Q system. However, the absorbed dose determined at the tissue level is incapable of providing information on single hits on (doses to) the single cell. As a result, it is necessary to resort to microdosimetry, which is capable of providing not only the number of hits on cells, but the distribution of hit sizes as well. From this information, an HSEF can be derived. However, to date there have been no sets of data available on animals exposed to radiations of several qualities, and for which microdosimetric data were available. The objective of the present set of experiments was to remedy this situation. Large numbers of mice were exposed to radiations of several different qualities, and were observed throughout their entire lifespan for the appearance of myeloid leukemia. The HSEF developed for this neoplasm is presented and discussed.

Physical Description

7 p.

Notes

INIS; OSTI as DE97000009

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  • 12. symposium on microdosimetry - interdisciplinary meeting on radiation quality, molecular mechanisms, cellular effects and health consequences of low level ionising radiation, Oxford (United Kingdom), 29 Sep - 4 Oct 1996

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  • Other: DE97000009
  • Report No.: BNL--63474
  • Report No.: CONF-960929--1
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 392794
  • Archival Resource Key: ark:/67531/metadc678042

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • October 1, 1996

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  • July 25, 2015, 2:20 a.m.

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  • Nov. 20, 2015, 8:54 p.m.

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Bond, V.P.; Cronkite, E.P.; Bullis, J.E.; Wuu, C.S.; Marino, S.A. & Zaider, M. An HSEF for murine myeloid leukemia, article, October 1, 1996; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc678042/: accessed October 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.