MEG-based imaging of focal neuronal current sources

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We describe a new approach to imaging neuronal current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Previous approaches to this problem have concentrated on the use of weighted minimum norm inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. We describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neuronal current sources associated with evoked response data. ... continued below

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5 p.

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Phillips, J. W.; Leahy, R. M. & Mosher, J. C. July 1, 1996.

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Description

We describe a new approach to imaging neuronal current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Previous approaches to this problem have concentrated on the use of weighted minimum norm inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. We describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neuronal current sources associated with evoked response data. The prior involves a binary process indicating active sources and a continuous Gaussian process designating associated amplitudes. An estimate of the primary current source distribution for a specific data set is formed by maximizing over the posterior probability with respect to the binary and continuous variables.

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5 p.

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OSTI as DE96012734

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  • Biomagnetism conference, Santa Fe, NM (United States), Feb 1996

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  • Other: DE96012734
  • Report No.: LA-UR--96-1942
  • Report No.: CONF-9602101--8
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 400182
  • Archival Resource Key: ark:/67531/metadc677297

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  • July 1, 1996

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  • July 25, 2015, 2:20 a.m.

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  • Oct. 3, 2017, 7:25 p.m.

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Phillips, J. W.; Leahy, R. M. & Mosher, J. C. MEG-based imaging of focal neuronal current sources, article, July 1, 1996; New Mexico. (digital.library.unt.edu/ark:/67531/metadc677297/: accessed January 23, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.