Mice, myths, and men

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Description

The author discusses some examples of how different experimental animal systems have helped to answer questions about the effects of radiation, in particular, carcinogenesis, and to indicate how the new experimental model systems promise an even more exciting future. Entwined in these themes will be observations about susceptibility and extrapolation across species. The hope of developing acceptable methods of extrapolation of estimates of the risk of radiogenic cancer increases as molecular biology reveals the trail of remarkable similarities in the genetic control of many functions common to many species. A major concern about even attempting to extrapolate estimates of risks ... continued below

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67 p.

Creation Information

Fry, R.J.M. December 31, 1994.

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  • Fry, R.J.M. Oak Ridge National Lab., TN (United States). Biology Div.

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Description

The author discusses some examples of how different experimental animal systems have helped to answer questions about the effects of radiation, in particular, carcinogenesis, and to indicate how the new experimental model systems promise an even more exciting future. Entwined in these themes will be observations about susceptibility and extrapolation across species. The hope of developing acceptable methods of extrapolation of estimates of the risk of radiogenic cancer increases as molecular biology reveals the trail of remarkable similarities in the genetic control of many functions common to many species. A major concern about even attempting to extrapolate estimates of risks of radiation-induced cancer across species has been that the mechanisms of carcinogenesis were so different among different species that it would negate the validity of extrapolation. The more that has become known about the genes involved in cancer, especially those related to the initial events in carcinogenesis, the more have the reasons for considering methods of extrapolation across species increased.

Physical Description

67 p.

Notes

INIS; OSTI as DE95008784

Source

  • National Council on Radiation Protection and Measurement (NCRP) conference, Bethesda, MD (United States), 6 Apr 1994

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  • Other: DE95008784
  • Report No.: CONF-9404248--1
  • Grant Number: AC05-84OR21400
  • DOI: 10.2172/41272 | External Link
  • Office of Scientific & Technical Information Report Number: 41272
  • Archival Resource Key: ark:/67531/metadc676862

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • December 31, 1994

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Jan. 25, 2016, 8:04 p.m.

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Fry, R.J.M. Mice, myths, and men, report, December 31, 1994; Tennessee. (digital.library.unt.edu/ark:/67531/metadc676862/: accessed December 13, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.