HIV transcription is induced with some forms of cell killing

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Description

Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.

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19 p.

Creation Information

Woloschak, G.E.; Schreck, S.; Panozzo, J.; Chang-Liu, C.-M. & Libertin, C.R. November 1, 1996.

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  • Woloschak, G.E. Argonne National Lab., IL (United States)
  • Schreck, S. South Carolina Univ., Columbia, SC (United States). Dept. of Chemistry
  • Panozzo, J. Loyola Univ. Medical Center, Maywood, IL (United States)
  • Chang-Liu, C.-M. Argonne National Lab., IL (United States)
  • Libertin, C.R. Loyola Univ. Medical Center, Maywood, IL (United States)

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Description

Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.

Physical Description

19 p.

Notes

INIS; OSTI as DE97001021

Source

  • Other Information: PBD: [1996]

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Identifier

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  • Other: DE97001021
  • Report No.: ANL/CMB/PP--83769
  • Grant Number: W-31109-ENG-38
  • DOI: 10.2172/405748 | External Link
  • Office of Scientific & Technical Information Report Number: 405748
  • Archival Resource Key: ark:/67531/metadc676835

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • November 1, 1996

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

Description Last Updated

  • Dec. 14, 2015, 6:26 p.m.

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Woloschak, G.E.; Schreck, S.; Panozzo, J.; Chang-Liu, C.-M. & Libertin, C.R. HIV transcription is induced with some forms of cell killing, report, November 1, 1996; Illinois. (digital.library.unt.edu/ark:/67531/metadc676835/: accessed October 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.